The Gut-Lung Axis in Cystic Fibrosis.

Price, Courtney E; O'Toole, George A

Price, Courtney E; O'Toole, George A.

Afiliación

Price CE; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover New Hampshire, USA.
O'Toole GA; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover New Hampshire, USA.

J Bacteriol ; 203(20): e0031121, 2021 09 23.

Article en En | MEDLINE | ID: mdl-34339302

RESUMEN

Cystic fibrosis (CF) is a heritable, multiorgan disease that impacts all tissues that normally express cystic fibrosis transmembrane conductance regulator (CFTR) protein. While the importance of the airway microbiota has long been recognized, the intestinal microbiota has only recently been recognized as an important player in both intestinal and lung health outcomes for persons with CF (pwCF). Here, we summarize current literature related to the gut-lung axis in CF, with a particular focus on three key ideas: (i) mechanisms through which microbes influence the gut-lung axis, (ii) drivers of microbiota alterations, and (iii) the potential for intestinal microbiota remediation.

Asunto(s)

Regulador de Conductancia de Transmembrana de Fibrosis Quística/metabolismo; Fibrosis Quística/microbiología; Pulmón/microbiología; Regulador de Conductancia de Transmembrana de Fibrosis Quística/genética; Microbioma Gastrointestinal; Humanos

Palabras clave

cystic fibrosis; gut-lung axis; inflammation; intestine; microbiota

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulador de Conductancia de Transmembrana de Fibrosis Quística / Fibrosis Quística / Pulmón Límite: Humans Idioma: En Revista: J Bacteriol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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