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Cancer Cytomembrane-Cloaked Prussian Blue Nanoparticles Enhance the Efficacy of Mild-Temperature Photothermal Therapy by Disrupting Mitochondrial Functions of Cancer Cells.
Wang, Pei; Kankala, Ranjith Kumar; Chen, Biaoqi; Zhang, Yang; Zhu, Mingzhi; Li, Xuemei; Long, Ruimin; Yang, Dayun; Krastev, Rumen; Wang, Shibin; Xiong, Xin; Liu, Yuangang.
Afiliación
  • Wang P; Fujian Provincial Key Laboratory of Biochemical Technology, Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, P. R. China.
  • Kankala RK; Jiangxi Key Laboratory of Stomatology and Biomedicine, School of Stomatology, Nanchang University, Nanchang 330006, P. R. China.
  • Chen B; Fujian Provincial Key Laboratory of Biochemical Technology, Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, P. R. China.
  • Zhang Y; Fujian Provincial Key Laboratory of Biochemical Technology, Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, P. R. China.
  • Zhu M; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361021, P. R. China.
  • Li X; Fujian Provincial Key Laboratory of Biochemical Technology, Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, P. R. China.
  • Long R; Fujian Provincial Key Laboratory of Biochemical Technology, Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, P. R. China.
  • Yang D; Fujian Provincial Key Laboratory of Biochemical Technology, Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, P. R. China.
  • Krastev R; Institute for Translational Medicine, School of Basic Medical Science, Fujian Medical University, Fuzhou 350122, P. R. China.
  • Wang S; Faculty for Applied Chemistry, Reutlingen University, Alteburgstr, 150, Reutlingen 72762, Germany.
  • Xiong X; Fujian Provincial Key Laboratory of Biochemical Technology, Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, P. R. China.
  • Liu Y; NMI Natural and Medical Sciences Institute, University of Tübingen, Markwiesenstr, 55, Reutlingen 72770, Germany.
ACS Appl Mater Interfaces ; 13(31): 37563-37577, 2021 Aug 11.
Article en En | MEDLINE | ID: mdl-34338525
Despite its success against cancer, photothermal therapy (PTT) (>50 °C) suffers from several limitations such as triggering inflammation and facilitating immune escape and metastasis and also damage to the surrounding normal cells. Mild-temperature PTT has been proposed to override these shortcomings. We developed a nanosystem using HepG2 cancer cell membrane-cloaked zinc glutamate-modified Prussian blue nanoparticles with triphenylphosphine-conjugated lonidamine (HmPGTL NPs). This innovative approach achieved an efficient mild-temperature PTT effect by downregulating the production of intracellular ATP. This disrupts a section of heat shock proteins that cushion cancer cells against heat. The physicochemical properties, anti-tumor efficacy, and mechanisms of HmPGTL NPs both in vitro and in vivo were investigated. Moreover, the nanoparticles cloaked with the HepG2 cell membrane substantially prolonged the circulation time in vivo. Overall, the designed nanocomposites enhance the efficacy of mild-temperature PTT by disrupting the production of ATP in cancer cells. Thus, we anticipate that the mild-temperature PTT nanosystem will certainly present its enormous potential in various biomedical applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Membrana Celular / Nanopartículas / Ferrocianuros / Mitocondrias / Neoplasias / Antineoplásicos Límite: Animals / Female / Humans Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Membrana Celular / Nanopartículas / Ferrocianuros / Mitocondrias / Neoplasias / Antineoplásicos Límite: Animals / Female / Humans Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos