Hippocampal neurogenesis mediates sex-specific effects of social isolation and exercise on fear extinction in adolescence.
Neurobiol Stress
; 15: 100367, 2021 Nov.
Article
en En
| MEDLINE
| ID: mdl-34337114
Impaired extinction of conditioned fear is associated with anxiety disorders. Common lifestyle factors, like isolation stress and exercise, may alter the ability to extinguish fear. However, the effect of and interplay between these factors on adolescent fear extinction, and the relevant underlying neural mechanisms are unknown. Here we examined the effects of periadolescent social isolation and physical activity on adolescent fear extinction in rats and explored neurogenesis as a potential mechanism. Isolation stress impaired extinction recall in male adolescents, an effect prevented by exercise. Extinction recall in female adolescents was unaffected by isolation stress. However, exercise disrupted extinction recall in isolated females. Extinction recall in isolated females was positively correlated to the number of immature neurons in the ventral hippocampus, suggesting that exercise affected extinction recall via neurogenesis in females. Pharmacologically suppressing cellular proliferation in isolated adolescents using temozolomide blocked the effect of exercise on extinction recall in both sexes. Together, these findings highlight sex-specific outcomes of isolation stress and exercise on adolescent brain and behavior, and highlights neurogenesis as a potential mechanism underlying lifestyle effects on adolescent fear extinction.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Aspecto:
Determinantes_sociais_saude
Idioma:
En
Revista:
Neurobiol Stress
Año:
2021
Tipo del documento:
Article
País de afiliación:
Australia
Pais de publicación:
Estados Unidos