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Fitness dependence preserves selection for recombination across diverse mixed mating strategies.
Rybnikov, Sviatoslav; Weissman, Daniel B; Hübner, Sariel; Korol, Abraham B.
Afiliación
  • Rybnikov S; Institute of Evolution, University of Haifa, Haifa 3498838, Israel; Department of Evolutionary and Environmental Biology, University of Haifa, Haifa 3498838, Israel. Electronic address: sviatoslav.rybnikov@gmail.com.
  • Weissman DB; Department of Physics, Emory University, Atlanta 30322 GA, USA.
  • Hübner S; Institute of Evolution, University of Haifa, Haifa 3498838, Israel; Galilee Research Institute (MIGAL), Tel-Hai College, Upper Galilee 1220800, Israel.
  • Korol AB; Institute of Evolution, University of Haifa, Haifa 3498838, Israel; Department of Evolutionary and Environmental Biology, University of Haifa, Haifa 3498838, Israel.
J Theor Biol ; 528: 110849, 2021 11 07.
Article en En | MEDLINE | ID: mdl-34331961
Meiotic recombination and the factors affecting its rate and fate in nature have inspired many studies in theoretical evolutionary biology. Classical theoretical models have inferred that recombination can be favored under a rather restricted parameter range. Thus, the ubiquity of recombination in nature remains an open question. However, these models assumed constant recombination with an equal rate across all individuals within the population, whereas empirical evidence suggests that recombination may display certain sensitivity to ecological stressors and/or genotype fitness. Models assuming condition-dependent recombination show that such a strategy can often be favored over constant recombination. Moreover, in our recent model with panmictic populations subjected to purifying selection, fitness-dependent recombination was quite often favored even when any constant recombination was rejected. By using numerical modeling, we test whether such a 'recombination-rescuing potential' of fitness dependence holds also beyond panmixia, given the recognized effect of mating strategy on the evolution of recombination. We show that deviations from panmixia generally increase the recombination-rescuing potential of fitness dependence, with the strongest effect under intermediate selfing or high clonality. We find that under partial clonality, the evolutionary advantage of fitness-dependent recombination is determined mostly by selection against heterozygotes and additive-by-additive epistasis, while under partial selfing, additive-by-dominance epistasis is also a driver.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reproducción / Modelos Genéticos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Theor Biol Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reproducción / Modelos Genéticos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Theor Biol Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido