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Atlas-Based Quantification of DTI Measures in a Typically Developing Pediatric Spinal Cord.
Shahrampour, S; De Leener, B; Alizadeh, M; Middleton, D; Krisa, L; Flanders, A E; Faro, S H; Cohen-Adad, J; Mohamed, F B.
Afiliación
  • Shahrampour S; From the Departments of Radiology (S.S., M.A., D.M., F.B.M.) feroze.mohamed@jefferson.edu.
  • De Leener B; Department of Computer Engineering and Software Engineering (B.D.L.).
  • Alizadeh M; From the Departments of Radiology (S.S., M.A., D.M., F.B.M.).
  • Middleton D; From the Departments of Radiology (S.S., M.A., D.M., F.B.M.).
  • Krisa L; Occupational Therapy (L.K.).
  • Flanders AE; Radiology (A.E.F., S.H.F.), Thomas Jefferson University, Philadelphia, Pennsylvania.
  • Faro SH; Radiology (A.E.F., S.H.F.), Thomas Jefferson University, Philadelphia, Pennsylvania.
  • Cohen-Adad J; NeuroPoly Lab (J.C.-A.), Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, Quebec, Canada.
  • Mohamed FB; Functional Neuroimaging Unit (J.C.-A.), Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Université de Montréal, Montreal, Quebec, Canada.
AJNR Am J Neuroradiol ; 42(9): 1727-1734, 2021 09.
Article en En | MEDLINE | ID: mdl-34326104
BACKGROUND AND PURPOSE: Multi-parametric MRI, provides a variety of biomarkers sensitive to white matter integrity, However, spinal cord MRI data in pediatrics is rare compared to adults. The purpose of this work was 3-fold: 1) to develop a processing pipeline for atlas-based generation of the typically developing pediatric spinal cord WM tracts, 2) to derive atlas-based normative values of the DTI indices for various WM pathways, and 3) to investigate age-related changes in the obtained normative DTI indices along the extracted tracts. MATERIALS AND METHODS: DTI scans of 30 typically developing subjects (age range, 6-16 years) were acquired on a 3T MR imaging scanner. The data were registered to the PAM50 template in the Spinal Cord Toolbox. Next, the DTI indices for various WM regions were extracted at a single section centered at the C3 vertebral body in all the 30 subjects. Finally, an ANOVA test was performed to examine the effects of the following: 1) laterality, 2) functionality, and 3) age, with DTI-derived indices in 34 extracted WM regions. RESULTS: A postprocessing pipeline was developed and validated to delineate pediatric spinal cord WM tracts. The results of ANOVA on fractional anisotropy values showed no effect for laterality (P = .72) but an effect for functionality (P < .001) when comparing the 30 primary WM labels. There was a significant (P < .05) effect of age and maturity of the left spinothalamic tract on mean diffusivity, radial diffusivity, and axial diffusivity values. CONCLUSIONS: The proposed automated pipeline in this study incorporates unique postprocessing steps followed by template registration and quantification of DTI metrics using atlas-based regions. This method eliminates the need for manual ROI analysis of WM tracts and, therefore, increases the accuracy and speed of the measurements.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pediatría / Sustancia Blanca Límite: Adolescent / Adult / Child / Humans Idioma: En Revista: AJNR Am J Neuroradiol Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pediatría / Sustancia Blanca Límite: Adolescent / Adult / Child / Humans Idioma: En Revista: AJNR Am J Neuroradiol Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos