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Engineering a safe monoclonal anti-human IL-2 that is effective in a murine model of food allergy and asthma.
Klein, Martin; Misme-Aucouturier, Barbara; Cheminant, Marie-Aude; De Carvalho, Marion; Wauters, Marie; Tranquet, Olivier; Magnan, Antoine; Bouchaud, Grégory.
Afiliación
  • Klein M; Université de Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
  • Misme-Aucouturier B; Biopolymères Intéractions Assemblages (BIA), INRAE, Nantes, France.
  • Cheminant MA; Université de Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
  • De Carvalho M; Biopolymères Intéractions Assemblages (BIA), INRAE, Nantes, France.
  • Wauters M; GZA Hospital & Health Care, Antwerpen, Belgium.
  • Tranquet O; Biopolymères Intéractions Assemblages (BIA), INRAE, Nantes, France.
  • Magnan A; Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
  • Bouchaud G; Biopolymères Intéractions Assemblages (BIA), INRAE, Nantes, France.
Allergy ; 77(3): 933-945, 2022 03.
Article en En | MEDLINE | ID: mdl-34324715
BACKGROUND: Regulatory T cells (Tregs) are known to protect against allergies. Moreover, the decrease in the frequency and efficiency of Tregs amplifies allergic symptoms. AIM: This study investigated whether expanding Tregs in vivo with an IL-2/IL-2 antibody complex could be safe, well tolerated and efficient in a therapeutic setting in allergies. METHODS: We produced an anti-IL-2 antibody (1C6) and demonstrated that when it is complexed to human IL-2, it increases IL-2 efficiency to induce Tregs in vivo without any detectable side effects. Furthermore, the IL-2/1C6 complex induces an increase in Helios expression by Tregs, suggesting that it not only elevated Treg numbers but also boosted their functions. Using mouse models of house-dust-mite-induced airway inflammation and wheat-gliadin-induced food allergies, we investigated the therapeutic potential of the IL-2/1C6 complex in allergies. RESULTS: IL-2/1C6 treatment significantly reduced allergic symptoms, specific IgE production, the adaptive immune response and tissue damage. Interestingly, IL-2/1C6 treatment modulated innate lymphoid cells by increasing ILC2s in asthma and decreasing ILC3s in food allergies. CONCLUSION: In conclusion,complexed IL-2/anti-IL-2 may restore Treg numbers and function in respiratory and food allergies, thereby improving allergic markers and symptoms. Our IL-2/anti-IL-2 complex offers new hope for reestablishing immune tolerance in patients with allergies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Hipersensibilidad a los Alimentos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Allergy Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Dinamarca
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Hipersensibilidad a los Alimentos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Allergy Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Dinamarca