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The IL-1 Receptor Is Required to Maintain Neutrophil Viability and Function During Aspergillus fumigatus Airway Infection.
Ralph, Benjamin Awr; Lehoux, Melanie; Ostapska, Hanna; Snarr, Brendan D; Caffrey-Carr, Alayna K; Fraser, Richard; Saleh, Maya; Obar, Joshua J; Qureshi, Salman T; Sheppard, Donald C.
Afiliación
  • Ralph BA; Department of Microbiology and Immunology, McGill University, Montréal, QC, Canada.
  • Lehoux M; Program in Infectious Diseases and Immunology in Global Health, Centre for Translational Biology, The Research Institute of the McGill University Health Center (RI-MUHC), Montréal, QC, Canada.
  • Ostapska H; Program in Infectious Diseases and Immunology in Global Health, Centre for Translational Biology, The Research Institute of the McGill University Health Center (RI-MUHC), Montréal, QC, Canada.
  • Snarr BD; Department of Microbiology and Immunology, McGill University, Montréal, QC, Canada.
  • Caffrey-Carr AK; Program in Infectious Diseases and Immunology in Global Health, Centre for Translational Biology, The Research Institute of the McGill University Health Center (RI-MUHC), Montréal, QC, Canada.
  • Fraser R; Department of Microbiology and Immunology, McGill University, Montréal, QC, Canada.
  • Saleh M; Program in Infectious Diseases and Immunology in Global Health, Centre for Translational Biology, The Research Institute of the McGill University Health Center (RI-MUHC), Montréal, QC, Canada.
  • Obar JJ; Department of Microbiology & Immunology, Dartmouth College, Lebanon, NH, United States.
  • Qureshi ST; Department of Medicine, McGill University, Montréal, QC, Canada.
  • Sheppard DC; Department of Microbiology and Immunology, McGill University, Montréal, QC, Canada.
Front Immunol ; 12: 675294, 2021.
Article en En | MEDLINE | ID: mdl-34322116
Aspergillus fumigatus airway infections are associated with increased rates of hospitalizations and declining lung function in patients with chronic lung disease. While the pathogenesis of invasive A. fumigatus infections is well studied, little is known about the development and progression of airway infections. Previous studies have demonstrated a critical role for the IL-1 cytokines, IL-1α and IL-1ß in enhancing pulmonary neutrophil recruitment during invasive aspergillosis. Here we use a mouse model of A. fumigatus airway infection to study the role of these IL-1 cytokines in immunocompetent mice. In the absence of IL-1 receptor signaling, mice exhibited reduced numbers of viable pulmonary neutrophils and increased levels of neutrophil apoptosis during fungal airway infection. Impaired neutrophil viability in these mice was associated with reduced pulmonary and systemic levels of G-CSF, and treatment with G-CSF restored both neutrophil viability and resistance to A. fumigatus airway infection. Taken together, these data demonstrate that IL-1 dependent G-CSF production plays a key role for host resistance to A. fumigatus airway infection through suppressing neutrophil apoptosis at the site of infection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aspergilosis / Aspergillus fumigatus / Receptores de Interleucina-1 / Aspergilosis Pulmonar / Pulmón / Neutrófilos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Front Immunol Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aspergilosis / Aspergillus fumigatus / Receptores de Interleucina-1 / Aspergilosis Pulmonar / Pulmón / Neutrófilos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Front Immunol Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza