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Defining Age-specific Relationships of Respiratory Syncytial Virus and Rhinovirus Species in Hospitalized Children With Acute Wheeze.
Oo, Stephen W C; Khoo, Siew-Kim; Cox, Des W; Chidlow, Glenys; Franks, Kimberley; Prastanti, Franciska; Bochkov, Yury A; Borland, Meredith L; Zhang, Guicheng; Gern, James E; Smith, David W; Bizzintino, Joelene A; Laing, Ingrid A; Le Souëf, Peter N.
Afiliación
  • Oo SWC; From the Division of Paediatrics, Faculty of Health and Medical Sciences, University of Western Australia.
  • Khoo SK; Respiratory Department, Perth Children's Hospital.
  • Cox DW; From the Division of Paediatrics, Faculty of Health and Medical Sciences, University of Western Australia.
  • Chidlow G; Children's Respiratory Science Group, Telethon Kids Institute, Perth, Western Australia.
  • Franks K; From the Division of Paediatrics, Faculty of Health and Medical Sciences, University of Western Australia.
  • Prastanti F; PathWest Laboratory Medicine WA, Perth, Western Australia.
  • Bochkov YA; From the Division of Paediatrics, Faculty of Health and Medical Sciences, University of Western Australia.
  • Borland ML; Children's Respiratory Science Group, Telethon Kids Institute, Perth, Western Australia.
  • Zhang G; From the Division of Paediatrics, Faculty of Health and Medical Sciences, University of Western Australia.
  • Gern JE; Children's Respiratory Science Group, Telethon Kids Institute, Perth, Western Australia.
  • Smith DW; Department of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Bizzintino JA; From the Division of Paediatrics, Faculty of Health and Medical Sciences, University of Western Australia.
  • Laing IA; Emergency Department, Perth Children's Hospital.
  • Le Souëf PN; Divisions of Emergency Medicine, Faculty of Health and Medical Sciences, University of Western Australia.
Pediatr Infect Dis J ; 40(10): 873-879, 2021 10 01.
Article en En | MEDLINE | ID: mdl-34321447
BACKGROUND: Acute wheezing is one of the most common hospital presentations for young children. Respiratory syncytial virus (RSV) and rhinovirus (RV) species A, B and the more recently described species C are implicated in the majority of these presentations. However, the relative importance and age-specificities of these viruses have not been defined. Hence, this study aimed to establish these relationships in a large cohort of prospectively recruited hospitalized children. METHODS: The study cohort was 390 children 0-16 years of age presenting with acute wheezing to a children's emergency department, 96.4% being admitted. A nonwheezing control population of 190 was also recruited. Nasal samples were analyzed for viruses. RESULTS: For the first 6 months of life, RSV was the dominant virus associated with wheezing (P < 0.001). From 6 months to 2 years, RSV, RV-A and RV-C were all common but none predominated. From 2 to 6 years, RV-C was the dominant virus detected (50-60% of cases), 2-3 times more common than RV-A and RSV, RSV decreasing to be absent from 4 to 7 years. RV-B was rare at all ages. RV-C was no longer dominant in children more than 10 years of age. Overall, RV-C was associated with lower mean oxygen saturation than any other virus (P < 0.001). Controls had no clear age distribution of viruses. CONCLUSION: This study establishes a clear profile of age specificity of virus infections causing moderate to severe wheezing in children: RSV as the dominant cause in the first 6 months and RV-C in preschool-age children.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rhinovirus / Ruidos Respiratorios / Virus Sincitial Respiratorio Humano / Hospitalización Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: Pediatr Infect Dis J Asunto de la revista: DOENCAS TRANSMISSIVEIS / PEDIATRIA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rhinovirus / Ruidos Respiratorios / Virus Sincitial Respiratorio Humano / Hospitalización Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: Pediatr Infect Dis J Asunto de la revista: DOENCAS TRANSMISSIVEIS / PEDIATRIA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos