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Type I collagen promotes tumor progression of integrin ß1 positive gastric cancer through a BCL9L/ß-catenin signaling pathway.
Lv, Yalei; Shan, Yujie; Song, Lina; Zhao, Yufei; Lai, Ruixue; Su, Junyan; Zhang, Xiaoyun.
Afiliación
  • Lv Y; Department of Medical Oncology, The Fourth Hospital of Hebei Medical University, Hebei, China.
  • Shan Y; Department of Medical Oncology, The Fourth Hospital of Hebei Medical University, Hebei, China.
  • Song L; Department of Oncology, Cangzhou Central Hospital, Hebei, China.
  • Zhao Y; Department of Immunology and Rheumatology, The Fourth Hospital of Hebei Medical University, Hebei, China.
  • Lai R; Department of Immunology and Rheumatology, The Fourth Hospital of Hebei Medical University, Hebei, China.
  • Su J; Lifehealthcare Clinical Laboratories, Hangzhou, Zhejiang, China.
  • Zhang X; Department of Immunology and Rheumatology, The Fourth Hospital of Hebei Medical University, Hebei, China.
Aging (Albany NY) ; 13(14): 19064-19076, 2021 07 28.
Article en En | MEDLINE | ID: mdl-34319913
The mechanism of extracellular matrix induced tumor progression is poorly understood. Based on the TCGA database and clinical tumor tissues analysis, we observed abundant type I collagen expression in tumor tissues and poor overall survival in gastric patients with high integrin ß1 (ITGB1) expression. In vitro, our study found that 3D collagen culture promoted the capability of colony formation and growth in ITGB1 positive gastric cancer, whereas limited colony growth was observed in ITGB1 negative gastric cancer, suggesting the role of ITGB1 in type I collagen associated tumor progression. Mechanistically, we demonstrated that type I collagen was capable of promoting the activation of BCL9L/ß-catenin signaling pathway through ITGB1, thereby contributing to the gastric cancer development. Subsequently, ß-catenin signals further up-regulated the expression anti-apoptosis protein BCL2, leading to the chemo-resistance in gastric cancer cells. Blockade of ß-catenin signals efficiently improved the anticancer effects of chemotherapy, providing an innovative sight for clinical gastric cancer therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Factores de Transcripción / Integrina beta1 / Colágeno Tipo I / Proteínas de Unión al ADN / Beta Catenina Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Aging (Albany NY) Asunto de la revista: GERIATRIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Factores de Transcripción / Integrina beta1 / Colágeno Tipo I / Proteínas de Unión al ADN / Beta Catenina Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Aging (Albany NY) Asunto de la revista: GERIATRIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos