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Simultaneous electrochemical detection of guanine and adenine using reduced graphene oxide decorated with AuPt nanoclusters.
Mao, Brennan; Qian, Lanting; Govindhan, Maduraiveeran; Liu, Zhonggang; Chen, Aicheng.
Afiliación
  • Mao B; Department of Chemistry, Lakehead University, 955 Oliver Road, Thunder Bay, ON, P7B 5E1, Canada.
  • Qian L; Electrochemical Technology Centre, Department of Chemistry, University of Guelph, 50 Stone Road East, Guelph, ON, N1G 2W1, Canada.
  • Govindhan M; Department of Chemistry, Lakehead University, 955 Oliver Road, Thunder Bay, ON, P7B 5E1, Canada.
  • Liu Z; Department of Chemistry, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur, Chennai, Tamil Nadu, 603 203, India.
  • Chen A; Electrochemical Technology Centre, Department of Chemistry, University of Guelph, 50 Stone Road East, Guelph, ON, N1G 2W1, Canada.
Mikrochim Acta ; 188(8): 276, 2021 07 28.
Article en En | MEDLINE | ID: mdl-34319444
A rapid and sensitive electrochemical sensing platform is reported based on bimetallic gold-platinum nanoclusters (AuPtNCs) dispersed on reduced graphene oxide (rGO) for the simultaneous detection of guanine and adenine using square wave voltammetry (SWV). The synthesis of AuPtNCs-rGO nanocomposite was achieved by a simultaneous reduction of graphene oxide (GO) and metal ions (Au3+ and Pt4+) in an aqueous solution. The developed AuPtNCs-rGO electrochemical sensor with the optimized 50:50 bimetallic (Au:Pt) nanoclusters exhibited an outstanding electrocatalytic performance towards the simultaneous oxidation of guanine and adenine without the aid of any enzymes or mediators in physiological pH. The electrochemical sensor platform showed low detection limits of 60 nM and 100 nM (S/N = 3) for guanine and adenine, respectively, with high sensitivity and an extensive linear range from 1.0 µM to 0.2 mM for both guanine and adenine. The interference from the most common electrochemically active interferents, including ascorbic acid, uric acid, and dopamine, was almost negligible. The simultaneous sensing of guanine and adenine in denatured Salmon Sperm DNA sample was successfully achieved using the proposed platform, showing that the AuPtNCs-rGO nanocomposite could provide auspicious clinical diagnosis and biomedical applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenina / Aleaciones / Nanocompuestos / Nanopartículas del Metal / Grafito / Guanina Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Mikrochim Acta Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Austria
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenina / Aleaciones / Nanocompuestos / Nanopartículas del Metal / Grafito / Guanina Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Mikrochim Acta Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Austria