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Quantitative investigation of the effect of surgically induced hypoparathyroidism on cataract development.
Koçer, Ali Mert; Sekeroglu, Mehmet Ali; Önder, Çagatay Emir; Çevik, Seda; Sögüt, Furkan Emre; Kuskonmaz, Serife Mehlika; Doguizi, Sibel.
Afiliación
  • Koçer AM; Department of Ophthalmology, Dortyol Public Hospital, Dörtyol, Hatay, Turkey. alimertkocer@gmail.com.
  • Sekeroglu MA; Department of Ophthalmology, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.
  • Önder ÇE; Department of Endocrinology, Ankara Training and Research Hospital, Ankara, Turkey.
  • Çevik S; Department of Ophthalmology, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.
  • Sögüt FE; Department of Ophthalmology, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.
  • Kuskonmaz SM; Department of Endocrinology, Ankara Training and Research Hospital, Ankara, Turkey.
  • Doguizi S; Department of Ophthalmology, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.
J Bone Miner Metab ; 40(1): 92-100, 2022 Jan.
Article en En | MEDLINE | ID: mdl-34313840
INTRODUCTION: Although cataract formation is known in hypoparathyroidism, lens clarity and its correlation with clinical parameters have not been investigated quantitatively before in patients with hypoparathyroidism. The aim of this study was to compare the crystalline lens clarity of patients with surgically induced hypoparathyroidism and healthy subjects. MATERIALS AND METHODS: Forty female patients with surgically induced hypoparathyroidism and 38 age-matched healthy female subjects were enrolled in this study. Scheimpflug corneal topography was performed to measure lens density (LD) and thickness (LT). Serum calcium, inorganic phosphorus, parathyroid hormone (PTH) levels, and disease duration were recorded. RESULTS: No statistically significant difference was observed between the hypoparathyroidism and control groups in the Pentacam densitometry zones 1-2-3, LT, and average and maximum LD (p > 0.05 for all). Nine blue-dot-like, two cortical, and two posterior subcapsular cataracts were detected in the hypoparathyroidism group. The frequency of total and blue-dot-like cataracts was significantly higher in the hypoparathyroidism group than in the control group (p = 0.008 and p = 0.002, respectively). In the hypoparathyroidism group, a significant correlation was observed between the maximum LD and the hypoparathyroidism duration (ß = 0.420, p = 0.017), and the maximum LD and serum PTH level (ß = -0.332, p = 0.049). CONCLUSION: The clarity of the crystalline lens may decrease in surgically induced hypoparathyroidism patients depending on the disease duration and PTH levels. Additionally, this study detected an increased frequency of blue-dot-like cataract in the patient group, which may be due to the effect of hypoparathyroidism.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Catarata / Hipoparatiroidismo / Cristalino Tipo de estudio: Etiology_studies Límite: Female / Humans Idioma: En Revista: J Bone Miner Metab Asunto de la revista: METABOLISMO Año: 2022 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Catarata / Hipoparatiroidismo / Cristalino Tipo de estudio: Etiology_studies Límite: Female / Humans Idioma: En Revista: J Bone Miner Metab Asunto de la revista: METABOLISMO Año: 2022 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Japón