Mitochondrial Voltage-Dependent Anion Channel 1-Hexokinase-II Complex-Targeted Strategy for Melanoma Inhibition Using Designed Multiblock Peptide Amphiphiles.

Zhang, Fan; Angelova, Angelina; Garamus, Vasil M; Angelov, Borislav; Tu, Shuyang; Kong, Liangliang; Zhang, Xinlei; Li, Na; Zou, Aihua

Zhang, Fan; Angelova, Angelina; Garamus, Vasil M; Angelov, Borislav; Tu, Shuyang; Kong, Liangliang; Zhang, Xinlei; Li, Na; Zou, Aihua.

Afiliación

Zhang F; Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.
Angelova A; Université Paris-Saclay, CNRS, Institute Galien Paris-Saclay UMR8612, Châtenay-Malabry F-92290, France.
Garamus VM; Helmholtz-Zentrum Hereon, Geesthacht D-21502, Germany.
Angelov B; Institute of Physics, ELI Beamlines, Academy of Sciences of the Czech Republic, Na Slovance 2, Prague CZ-18221, Czech Republic.
Tu S; National Facility for Protein Science in Shanghai, Shanghai Advanced Research Institute (Zhangjiang Laboratory), Chinese Academy of Sciences, Shanghai 201210, China.
Kong L; National Facility for Protein Science in Shanghai, Shanghai Advanced Research Institute (Zhangjiang Laboratory), Chinese Academy of Sciences, Shanghai 201210, China.
Zhang X; Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.
Li N; National Facility for Protein Science in Shanghai, Shanghai Advanced Research Institute (Zhangjiang Laboratory), Chinese Academy of Sciences, Shanghai 201210, China.
Zou A; Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.

ACS Appl Mater Interfaces ; 13(30): 35281-35293, 2021 Aug 04.

Article en En | MEDLINE | ID: mdl-34309373

Asunto(s)

Antineoplásicos/farmacología; Hexoquinasa/metabolismo; Péptidos/farmacología; Tensoactivos/farmacología; Canal Aniónico 1 Dependiente del Voltaje/metabolismo; Secuencia de Aminoácidos; Apoptosis/efectos de los fármacos; Línea Celular Tumoral; Humanos; Potencial de la Membrana Mitocondrial/efectos de los fármacos; Mitocondrias/efectos de los fármacos; Membranas Mitocondriales/efectos de los fármacos

Palabras clave

VDAC1-derived amphiphilic peptides; cell-penetrating peptides (CPP); human melanoma cells; mitochondria-mediated apoptosis; protein−protein interaction inhibition; self-assembly; targeting VDAC1−HK-II complex

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Tensoactivos / Canal Aniónico 1 Dependiente del Voltaje / Hexoquinasa / Antineoplásicos Límite: Humans Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos

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