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CAR-T therapy in solid transplant recipients with post-transplant lymphoproliferative disease: case report and literature review.
Hernani, Rafael; Sancho, Asunción; Amat, Paula; Hernández-Boluda, Juan Carlos; Pérez, Ariadna; Piñana, Jose Luis; Carretero, Carlos; Goterris, Rosa; Gómez, Montse; Saus, Ana; Ferrer, Blanca; Teruel, Ana Isabel; Terol, María José; Solano, Carlos.
Afiliación
  • Hernani R; Haematology Department, Hospital Clínico Universitario, INCLIVA Biomedical Research Institute, 17 Blasco Ibáñez Avenue, 46010 Valencia, Spain. Electronic address: hernani_raf@gva.es.
  • Sancho A; Nephrology Department, Hospital Universitario Dr. Peset, Valencia, Spain.
  • Amat P; Haematology Department, Hospital Clínico Universitario, INCLIVA Biomedical Research Institute, 17 Blasco Ibáñez Avenue, 46010 Valencia, Spain; Department of Medicine, University of Valencia, Valencia, Spain.
  • Hernández-Boluda JC; Haematology Department, Hospital Clínico Universitario, INCLIVA Biomedical Research Institute, 17 Blasco Ibáñez Avenue, 46010 Valencia, Spain; Department of Medicine, University of Valencia, Valencia, Spain.
  • Pérez A; Haematology Department, Hospital Clínico Universitario, INCLIVA Biomedical Research Institute, 17 Blasco Ibáñez Avenue, 46010 Valencia, Spain.
  • Piñana JL; Haematology Department, Hospital Clínico Universitario, INCLIVA Biomedical Research Institute, 17 Blasco Ibáñez Avenue, 46010 Valencia, Spain; CIBERONC, Instituto Carlos III, Madrid, Spain.
  • Carretero C; Haematology Department, Hospital Clínico Universitario, INCLIVA Biomedical Research Institute, 17 Blasco Ibáñez Avenue, 46010 Valencia, Spain.
  • Goterris R; Haematology Department, Hospital Clínico Universitario, INCLIVA Biomedical Research Institute, 17 Blasco Ibáñez Avenue, 46010 Valencia, Spain.
  • Gómez M; Haematology Department, Hospital Clínico Universitario, INCLIVA Biomedical Research Institute, 17 Blasco Ibáñez Avenue, 46010 Valencia, Spain.
  • Saus A; Haematology Department, Hospital Clínico Universitario, INCLIVA Biomedical Research Institute, 17 Blasco Ibáñez Avenue, 46010 Valencia, Spain.
  • Ferrer B; Haematology Department, Hospital Clínico Universitario, INCLIVA Biomedical Research Institute, 17 Blasco Ibáñez Avenue, 46010 Valencia, Spain.
  • Teruel AI; Haematology Department, Hospital Clínico Universitario, INCLIVA Biomedical Research Institute, 17 Blasco Ibáñez Avenue, 46010 Valencia, Spain; Department of Medicine, University of Valencia, Valencia, Spain.
  • Terol MJ; Haematology Department, Hospital Clínico Universitario, INCLIVA Biomedical Research Institute, 17 Blasco Ibáñez Avenue, 46010 Valencia, Spain; Department of Medicine, University of Valencia, Valencia, Spain.
  • Solano C; Haematology Department, Hospital Clínico Universitario, INCLIVA Biomedical Research Institute, 17 Blasco Ibáñez Avenue, 46010 Valencia, Spain; Department of Medicine, University of Valencia, Valencia, Spain.
Curr Res Transl Med ; 69(4): 103304, 2021 10.
Article en En | MEDLINE | ID: mdl-34303899
Patients with postransplant lymphoproliferative disease (PTLD) who are refractory to rituximab-based regimens have extremely poor prognosis. Data is lacking in the setting of solid organ transplantation (SOT)-related PTLD treated with chimeric antigen receptor T-cell (CAR-T) therapy. Moreover, limited information is available on the influence of concomitant immunosuppressive drugs on CAR-T function. Here, we describe the clinical outcome in one PTLD patient and propose a strategy for tailoring immunosuppressive treatment and organ monitoring in patients with kidney allografts after CAR-T infusion. This report also reviews the limited published data in the setting of SOT-related PTLD treated with CAR-T, which appears to be a feasible treatment in this clinical scenario, without severe toxicity and capable of inducing sustained responses. A noteworthy finding is that in most reported cases patients underwent complete or partial discontinuation of immunosuppressive drugs, with only one documented case of allograft rejection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Órganos / Receptores Quiméricos de Antígenos / Trastornos Linfoproliferativos Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Curr Res Transl Med Año: 2021 Tipo del documento: Article Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Órganos / Receptores Quiméricos de Antígenos / Trastornos Linfoproliferativos Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Curr Res Transl Med Año: 2021 Tipo del documento: Article Pais de publicación: Francia