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Biosynthesis and physico-chemical characterization of high performing peptide hydrogels@graphene oxide composites.
Chronopoulou, Laura; Di Nitto, Antonio; Papi, Massimiliano; Parolini, Ornella; Falconi, Mirella; Teti, Gabriella; Muttini, Aurelio; Lattanzi, Wanda; Palmieri, Valentina; Ciasca, Gabriele; Del Giudice, Alessandra; Galantini, Luciano; Zanoni, Robertino; Palocci, Cleofe.
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  • Chronopoulou L; Department of Chemistry, University of Rome La Sapienza, Italy.
  • Di Nitto A; Department of Chemistry, University of Rome La Sapienza, Italy.
  • Papi M; Fondazione Policlinico Universitario A. Gemelli IRCSS, Rome, Italy.
  • Parolini O; Fondazione Policlinico Universitario A. Gemelli IRCSS, Rome, Italy.
  • Falconi M; Department of Biomedical and Neuromotor Sciences, University of Bologna, Italy.
  • Teti G; Department of Biomedical and Neuromotor Sciences, University of Bologna, Italy.
  • Muttini A; Faculty of Bioscience and Agro-Food and Environmental Technology, University of Teramo, Italy.
  • Lattanzi W; Fondazione Policlinico Universitario A. Gemelli IRCSS, Rome, Italy.
  • Palmieri V; Fondazione Policlinico Universitario A. Gemelli IRCSS, Rome, Italy.
  • Ciasca G; Fondazione Policlinico Universitario A. Gemelli IRCSS, Rome, Italy.
  • Del Giudice A; Department of Chemistry, University of Rome La Sapienza, Italy.
  • Galantini L; Department of Chemistry, University of Rome La Sapienza, Italy.
  • Zanoni R; Department of Chemistry, University of Rome La Sapienza, Italy.
  • Palocci C; Department of Chemistry, University of Rome La Sapienza, Italy; CIABC, University of Rome La Sapienza, Italy. Electronic address: cleofe.palocci@uniroma1.it.
Colloids Surf B Biointerfaces ; 207: 111989, 2021 Nov.
Article en En | MEDLINE | ID: mdl-34303114
Hydrogels based on short peptide molecules are interesting biomaterials with wide present and prospective use in biotechnologies. A well-known possible drawback of these materials can be their limited mechanical performance. In order to overcome this problem, we prepared Fmoc-Phe3self-assembling peptides by a biocatalytic approach, and we reinforced the hydrogel with graphene oxide nanosheets. The formulation here proposed confers to the hydrogel additional physicochemical properties without hampering peptide self-assembly. We investigated in depth the effect of nanocarbon morphology on hydrogel properties (i.e. morphology, viscoelastic properties, stiffness, resistance to an applied stress). In view of further developments towards possible clinical applications, we have preliminarily tested the biocompatibility of the composites. Our results showed that the innovative hydrogel composite formulation based on FmocPhe3 and GO is a biomaterial with improved mechanical properties that appears suitable for the development of biotechnological applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrogeles / Grafito Tipo de estudio: Observational_studies Idioma: En Revista: Colloids Surf B Biointerfaces Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrogeles / Grafito Tipo de estudio: Observational_studies Idioma: En Revista: Colloids Surf B Biointerfaces Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos