Your browser doesn't support javascript.
loading
A Multicentre, Randomised, Controlled Trial of a Combined Clinical Treatment for First-Episode Psychosis.
González-Ortega, Itxaso; Vega, Patricia; Echeburúa, Enrique; Alberich, Susana; Fernández-Sevillano, Jessica; Barbeito, Sara; Balanzá-Martínez, Vicent; Vieta, Eduard; Lorente-Rovira, Esther; Luengo, Ana; Cerrillo, Ester; Crespo, José Manuel; Matute, Carlos; González-Pinto, Ana.
Afiliación
  • González-Ortega I; Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain.
  • Vega P; Bioaraba Research Institute, Department of Psychiatry, Araba University Hospital, 01004 Vitoria, Spain.
  • Echeburúa E; Department of Personality, Assessment and Psychological Treatment, National University of Distance Education (UNED), 01008 Vitoria, Spain.
  • Alberich S; Department of Neurosciences, University of the Basque Country, 48940 Leioa, Spain.
  • Fernández-Sevillano J; Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain.
  • Barbeito S; Bioaraba Research Institute, Department of Psychiatry, Araba University Hospital, 01004 Vitoria, Spain.
  • Balanzá-Martínez V; Department of Neurosciences, University of the Basque Country, 48940 Leioa, Spain.
  • Vieta E; Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain.
  • Lorente-Rovira E; Department of Personality, Assessment and Psychological Treatment, University of the Basque Country, Biodonostia, 20018 San Sebastian, Spain.
  • Luengo A; Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain.
  • Cerrillo E; Bioaraba Research Institute, Department of Psychiatry, Araba University Hospital, 01004 Vitoria, Spain.
  • Crespo JM; Department of Fundamental Mathematics, National University of Distance Education (UNED), 01008 Vitoria, Spain.
  • Matute C; Centre for Biomedical Research in the Mental Health Network (CIBERSAM), 28029 Madrid, Spain.
  • González-Pinto A; Bioaraba Research Institute, Department of Psychiatry, Araba University Hospital, 01004 Vitoria, Spain.
Int J Environ Res Public Health ; 18(14)2021 07 06.
Article en En | MEDLINE | ID: mdl-34299697
INTRODUCTION: There is evidence that early intervention contributes to improving the prognosis and course of first-episode psychosis (FEP). However, further randomised treatment clinical trials are needed. OBJECTIVES: The aim of this study was to compare the efficacy of a combined clinical treatment involving Cognitive Behavioural Therapy (CBT) as an adjunctive to treatment-as-usual (TAU) (CBT+TAU) versus TAU alone for FEP. PATIENTS AND METHODS: In this multicentre, single-blind, randomised controlled trial, 177 participants were randomly allocated to either CBT+TAU or TAU. The primary outcome was post-treatment patient functioning. RESULTS: The CBT+TAU group showed a greater improvement in functioning, which was measured using the Global Assessment Functioning (GAF) and Functioning Assessment Short Test (FAST), compared to the TAU group post-treatment. The CBT+TAU participants exhibited a greater decline in depressive, negative, and general psychotic symptoms; a better awareness of the disease and treatment adherence; and a greater increase in brain-derived neurotrophic factor levels than TAU participants. CONCLUSIONS: Early intervention based on a combined clinical treatment involving CBT as an adjunctive to standard treatment may improve clinical and functional outcomes in FEP.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Psicóticos / Terapia Cognitivo-Conductual Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Humans Idioma: En Revista: Int J Environ Res Public Health Año: 2021 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Psicóticos / Terapia Cognitivo-Conductual Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Humans Idioma: En Revista: Int J Environ Res Public Health Año: 2021 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza