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Orofacial Neuropathic Pain-Basic Research and Their Clinical Relevancies.
Shinoda, Masamichi; Imamura, Yoshiki; Hayashi, Yoshinori; Noma, Noboru; Okada-Ogawa, Akiko; Hitomi, Suzuro; Iwata, Koichi.
Afiliación
  • Shinoda M; Department of Physiology, Nihon University School of Dentistry, Tokyo, Japan.
  • Imamura Y; Department of Oral Diagnostic Sciences, Nihon University School of Dentistry, Tokyo, Japan.
  • Hayashi Y; Department of Physiology, Nihon University School of Dentistry, Tokyo, Japan.
  • Noma N; Department of Oral Diagnostic Sciences, Nihon University School of Dentistry, Tokyo, Japan.
  • Okada-Ogawa A; Department of Oral Diagnostic Sciences, Nihon University School of Dentistry, Tokyo, Japan.
  • Hitomi S; Department of Physiology, Nihon University School of Dentistry, Tokyo, Japan.
  • Iwata K; Department of Physiology, Nihon University School of Dentistry, Tokyo, Japan.
Front Mol Neurosci ; 14: 691396, 2021.
Article en En | MEDLINE | ID: mdl-34295221
Trigeminal nerve injury is known to cause severe persistent pain in the orofacial region. This pain is difficult to diagnose and treat. Recently, many animal studies have reported that rewiring of the peripheral and central nervous systems, non-neuronal cell activation, and up- and down-regulation of various molecules in non-neuronal cells are involved in the development of this pain following trigeminal nerve injury. However, there are many unknown mechanisms underlying the persistent orofacial pain associated with trigeminal nerve injury. In this review, we address recent animal data regarding the involvement of various molecules in the communication of neuronal and non-neuronal cells and examine the possible involvement of ascending pathways in processing pathological orofacial pain. We also address the clinical observations of persistent orofacial pain associated with trigeminal nerve injury and clinical approaches to their diagnosis and treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Mol Neurosci Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Mol Neurosci Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza