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Effects of 5.8 GHz microwave on hippocampal synaptic plasticity of rats.
Rui, Gang; Liu, Li-Yuan; Guo, Ling; Xue, Yi-Zhe; Lai, Pan-Pan; Gao, Peng; Xing, Jun-Ling; Li, Jing; Ding, Gui-Rong.
Afiliación
  • Rui G; Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, Xi'an, Shaanxi, China.
  • Liu LY; Department of Radiation Protection Medicine, Air Force Medical University, Xi'an, Shaanxi, China.
  • Guo L; Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, Xi'an, Shaanxi, China.
  • Xue YZ; Department of Radiation Protection Medicine, Air Force Medical University, Xi'an, Shaanxi, China.
  • Lai PP; Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, Xi'an, Shaanxi, China.
  • Gao P; Department of Radiation Protection Medicine, Air Force Medical University, Xi'an, Shaanxi, China.
  • Xing JL; Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, Xi'an, Shaanxi, China.
  • Li J; Department of Radiation Protection Medicine, Air Force Medical University, Xi'an, Shaanxi, China.
  • Ding GR; Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, Xi'an, Shaanxi, China.
Int J Environ Health Res ; 32(10): 2247-2259, 2022 Oct.
Article en En | MEDLINE | ID: mdl-34293966
OBJECTIVE: 5.8 GHz spectrum is gaining more attention in wireless technology. To explore the potential hazards, we investigated the effect of exposure to 5.8 GHz microwave on learning and memory ability of rats. Methods: Morris Water maze (MWM), Novel object recognition (NOR) and Fear conditioning test (FCT) were used to evaluate the ability of spatial and non-spatial memory of rats. The hippocampal morphology, the level of brain injury factors in serum and the mitochondrial membrane potential of hippocampal neurons was examined to evaluate the damage of hippocampal neurons. The density of dendritic spines, the ultrastructure of synapses and the level of PSD95, Synaptophysin, p-CREB and CREB were detected to evaluate the hippocampal synaptic plasticity. RESULTS: Compared with Sham group, there was no significant difference in the performance of ethology (in MWM, NOR, FCT) in Microwave 2 h group or Microwave 4 h group. The hippocampal morphology, the serum level of brain injury factors and the content of mitochondrial JC-1 monomer in Microwave 2 h group or Microwave 4 h group did not change obviously, compared with Sham group. The density of dendritic spines, the ultrastructure of synapse and the level of PSD95, Synaptophysin, p-CREB and CREB in hippocampus in Microwave 2 h group or Microwave 4 h group did not significantly change, compared with Sham group. CONCLUSION: Under this experimental condition, exposure to 5.8 GHz microwave could not affect the hippocampal synaptic plasticity of rats.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lesiones Encefálicas / Hipocampo Límite: Animals Idioma: En Revista: Int J Environ Health Res Asunto de la revista: SAUDE AMBIENTAL Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lesiones Encefálicas / Hipocampo Límite: Animals Idioma: En Revista: Int J Environ Health Res Asunto de la revista: SAUDE AMBIENTAL Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido