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Dynamic loading of human engineered heart tissue enhances contractile function and drives a desmosome-linked disease phenotype.
Bliley, Jacqueline M; Vermeer, Mathilde C S C; Duffy, Rebecca M; Batalov, Ivan; Kramer, Duco; Tashman, Joshua W; Shiwarski, Daniel J; Lee, Andrew; Teplenin, Alexander S; Volkers, Linda; Coffin, Brian; Hoes, Martijn F; Kalmykov, Anna; Palchesko, Rachelle N; Sun, Yan; Jongbloed, Jan D H; Bomer, Nils; de Boer, Rudolf A; Suurmeijer, Albert J H; Pijnappels, Daniel A; Bolling, Maria C; van der Meer, Peter; Feinberg, Adam W.
Afiliación
  • Bliley JM; Regenerative Biomaterials and Therapeutics Group, Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
  • Vermeer MCSC; Department of Cardiology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
  • Duffy RM; Regenerative Biomaterials and Therapeutics Group, Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
  • Batalov I; Regenerative Biomaterials and Therapeutics Group, Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
  • Kramer D; Department of Dermatology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
  • Tashman JW; Regenerative Biomaterials and Therapeutics Group, Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
  • Shiwarski DJ; Regenerative Biomaterials and Therapeutics Group, Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
  • Lee A; Regenerative Biomaterials and Therapeutics Group, Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
  • Teplenin AS; Department of Cardiology, Heart Lung Center Leiden, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
  • Volkers L; Department of Cardiology, Heart Lung Center Leiden, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
  • Coffin B; Department of Materials Science and Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
  • Hoes MF; Department of Cardiology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
  • Kalmykov A; Regenerative Biomaterials and Therapeutics Group, Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
  • Palchesko RN; Regenerative Biomaterials and Therapeutics Group, Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
  • Sun Y; Regenerative Biomaterials and Therapeutics Group, Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
  • Jongbloed JDH; Department of Genetics, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
  • Bomer N; Department of Cardiology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
  • de Boer RA; Department of Cardiology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
  • Suurmeijer AJH; Department of Pathology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
  • Pijnappels DA; Department of Cardiology, Heart Lung Center Leiden, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.
  • Bolling MC; Department of Dermatology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
  • van der Meer P; Department of Cardiology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, Netherlands. feinberg@andrew.cmu.edu p.van.der.meer@umcg.nl.
  • Feinberg AW; Regenerative Biomaterials and Therapeutics Group, Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA. feinberg@andrew.cmu.edu p.van.der.meer@umcg.nl.
Sci Transl Med ; 13(603)2021 07 21.
Article en En | MEDLINE | ID: mdl-34290054
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Desmosomas / Células Madre Pluripotentes Inducidas Límite: Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Desmosomas / Células Madre Pluripotentes Inducidas Límite: Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos