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Application of selected biosensor techniques in clinical diagnostics.
Olejnik, Beata; Koziol, Agata; Brzozowska, Ewa; Ferens-Sieczkowska, Miroslawa.
Afiliación
  • Olejnik B; Department of Chemistry and Immunochemistry, Medical University of Wroclaw, Wroclaw, Poland.
  • Koziol A; Department of Chemistry and Immunochemistry, Medical University of Wroclaw, Wroclaw, Poland.
  • Brzozowska E; Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Laboratory of Medical Microbiology, Wroclaw, Poland.
  • Ferens-Sieczkowska M; Department of Chemistry and Immunochemistry, Medical University of Wroclaw, Wroclaw, Poland.
Expert Rev Mol Diagn ; 21(9): 925-937, 2021 Sep.
Article en En | MEDLINE | ID: mdl-34289786
INTRODUCTION: Examination of disease biomarkers mostly performed on crude materials, such as serum, meets some obstacles, resulting from sample complexity and the wide range of concentrations and sizes of the components. Techniques currently used in clinical diagnostics are usually time-consuming and expensive. The more sensitive and portable devices are needed for early diagnostics. Chemical sensors are devices that convert chemical information into parameters suitable for fast and precise processing and measurement. AREA COVERED: We review the use of biosensors and their possible application in early diagnostics of some diseases like cancer or viral infections. We focus on different types of biorecognition and some technical modifications, lowering the limit of detection potentially attractive to medical practitioners. EXPERT OPINION: Among the new diagnostic strategies, the use of biosensors is of increasing interest. In these techniques, the capture ligand interacts with the analyte of interest. Measuring interactions between partners in real time by surface plasmon resonance yields valuable information about kinetics and affinity in a short time and without labels. Importantly, the tendency in such techniques is to make biosensor devices smaller and the test results apparent with the naked eye, so they can be used in point-of-care medicine.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Técnicas Biosensibles Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Expert Rev Mol Diagn Asunto de la revista: BIOLOGIA MOLECULAR Año: 2021 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Técnicas Biosensibles Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Expert Rev Mol Diagn Asunto de la revista: BIOLOGIA MOLECULAR Año: 2021 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido