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Benefits of D-005, a lipid extract from Acrocomia crispa fruits, in the prevention of acute kidney njury induced by nephrotoxicity in rats.
Rodríguez-Salgueiro, Sandra; Ocaña-Nápoles, Leyanis; Oyarzábal-Yera, Ambar; González-Núñez, Lucía; Breña-Betancourt, Giselle; Pérez-Pino, María Flavia; Medina-Pírez, José A; Jiménez-Despaigne, Sonia; Molina-Cuevas, Vivian.
Afiliación
  • Rodríguez-Salgueiro S; Centro Nacional de Investigación Científica, Departamento de Farmacología, Havana, Cuba.
  • Ocaña-Nápoles L; Facultad Latinoamericana de Medicina, Departamento de Ciencias Morfológicas, Havana, Cuba.
  • Oyarzábal-Yera A; Centro Nacional de Investigación Científica, Departamento de Farmacología, Havana, Cuba.
  • González-Núñez L; Centro Nacional de Investigación Científica, Departamento de Farmacología, Havana, Cuba.
  • Breña-Betancourt G; Facultad Latinoamericana de Medicina, Departamento de Ciencias Morfológicas, Havana, Cuba.
  • Pérez-Pino MF; Centro Nacional de Investigación Científica, Departamento de Farmacología, Havana, Cuba.
  • Medina-Pírez JA; Centro Nacional de Investigación Científica, Departamento de Farmacología, Havana, Cuba.
  • Jiménez-Despaigne S; Centro Nacional de Investigación Científica, Departamento de Farmacología, Havana, Cuba.
  • Molina-Cuevas V; Centro Nacional de Investigación Científica, Departamento de Farmacología, Havana, Cuba.
J Bras Nefrol ; 44(1): 9-18, 2022.
Article en En, Pt | MEDLINE | ID: mdl-34289007
INTRODUCTION: Aminoglycoside-induced acute kidney injury (AKI) is a pathology closely linked to oxidative and inflammatory reactions. Taking into account the previous reported antioxidant and anti-inflammatory effects of D-005, a lipid extract obtained from Cuban palm Acrocomia crispa (Arecaceae) fruits, this work aimed to evaluate the effects of D-005 on kanamycin-induced AKI. METHODS: Male Wistar rats were divided into 7 groups: negative control (vehicle, Tween 65/H2O) and six groups treated with kanamycin to induce AKI: positive control (vehicle), D-005 (25, 100, 200, and 400 mg/kg) and grape seed extract (GSE, 200 mg/kg). D-005, vehicle, and GSE oral treatments were administered once daily for seven days, 1 h before kanamycin (500 mg/kg, i.p.). Serum uric acid and urea concentrations, renal histopathology, and oxidative markers (malondialdehyde (MDA), sulfhydryl (SH) groups, and catalase (CAT) activity) were assessed. RESULTS: D-005 significantly reduced uric acid and urea levels, starting from D-005 100 mg/kg. Histopathologically, D-005, at all the tested doses, protected renal parenchyma structures (glomeruli, proximal tubules, and interstitium). These findings were accompanied by a significant reduction of MDA and SH group concentrations as well as restoration of CAT activity. The highest percentages of inhibition were obtained with the dose of 400 mg/kg. GSE, the reference substance, also prevented kanamycin-induced biochemical and histopathological changes, as well as reduced MDA and SH groups and restored CAT activity. CONCLUSION: The administration of repeated oral doses of D-005 significantly protected against kanamycin-induced AKI, which could be associated with the antioxidant and anti-inflammatory effects of this extract.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arecaceae / Lesión Renal Aguda Límite: Animals / Humans / Male Idioma: En / Pt Revista: J Bras Nefrol Asunto de la revista: NEFROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Cuba Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arecaceae / Lesión Renal Aguda Límite: Animals / Humans / Male Idioma: En / Pt Revista: J Bras Nefrol Asunto de la revista: NEFROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Cuba Pais de publicación: Brasil