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Differences in structural and functional default mode network connectivity in amyloid positive mild cognitive impairment: a longitudinal study.
Magalhães, Thamires Naela Cardoso; Gerbelli, Christian Luiz Baptista; Pimentel-Silva, Luciana Ramalho; de Campos, Brunno Machado; de Rezende, Thiago Junqueira Ribeiro; Rizzi, Liara; Joaquim, Helena Passarelli Giroud; Talib, Leda Leme; Forlenza, Orestes Vicente; Cendes, Fernando; Balthazar, Marcio Luiz Figueredo.
Afiliación
  • Magalhães TNC; Laboratory of Neuroimaging, Department of Neurology - Medical Sciences School, University of Campinas (UNICAMP), Rua Tessália Vieira de Camargo 126, Campinas, SP, 13083-887, Brazil. thamiresncm@hotmail.com.
  • Gerbelli CLB; Laboratory of Neuroimaging, Department of Neurology - Medical Sciences School, University of Campinas (UNICAMP), Rua Tessália Vieira de Camargo 126, Campinas, SP, 13083-887, Brazil.
  • Pimentel-Silva LR; Laboratory of Neuroimaging, Department of Neurology - Medical Sciences School, University of Campinas (UNICAMP), Rua Tessália Vieira de Camargo 126, Campinas, SP, 13083-887, Brazil.
  • de Campos BM; Laboratory of Neuroimaging, Department of Neurology - Medical Sciences School, University of Campinas (UNICAMP), Rua Tessália Vieira de Camargo 126, Campinas, SP, 13083-887, Brazil.
  • de Rezende TJR; Laboratory of Neuroimaging, Department of Neurology - Medical Sciences School, University of Campinas (UNICAMP), Rua Tessália Vieira de Camargo 126, Campinas, SP, 13083-887, Brazil.
  • Rizzi L; Laboratory of Neuroimaging, Department of Neurology - Medical Sciences School, University of Campinas (UNICAMP), Rua Tessália Vieira de Camargo 126, Campinas, SP, 13083-887, Brazil.
  • Joaquim HPG; Laboratory of Neurosciences, (LIM 27), Department and Institute of Psychiatry, University of São Paulo (USP), São Paulo, Brazil.
  • Talib LL; Laboratory of Neurosciences, (LIM 27), Department and Institute of Psychiatry, University of São Paulo (USP), São Paulo, Brazil.
  • Forlenza OV; Laboratory of Neurosciences, (LIM 27), Department and Institute of Psychiatry, University of São Paulo (USP), São Paulo, Brazil.
  • Cendes F; Laboratory of Neuroimaging, Department of Neurology - Medical Sciences School, University of Campinas (UNICAMP), Rua Tessália Vieira de Camargo 126, Campinas, SP, 13083-887, Brazil.
  • Balthazar MLF; Laboratory of Neuroimaging, Department of Neurology - Medical Sciences School, University of Campinas (UNICAMP), Rua Tessália Vieira de Camargo 126, Campinas, SP, 13083-887, Brazil.
Neuroradiology ; 64(1): 141-150, 2022 Jan.
Article en En | MEDLINE | ID: mdl-34278511
PURPOSE: Default mode network (DMN) has emerged as a potential biomarker of Alzheimer's disease (AD); however, it is not clear whether it can differentiate amnestic mild cognitive impairment with altered amyloid (aMCI-Aß +) who will evolve to AD. We evaluated if structural and functional connectivity (FC), hippocampal volumes (HV), and cerebrospinal fluid biomarkers (CSF-Aß42, p-Tau, and t-Tau) can differentiate aMCI-Aß + converters from non-converters. METHODS: Forty-eight individuals (18 normal controls and 30 aMCI subjects in the AD continuum - with altered Aß42 in the CSF) were followed up for an average of 13 months. We used MultiAtlas, UF2C, and Freesurfer software to evaluate diffusion tensor imaging, FC, and HV, respectively, INNOTEST® kits to measure CSF proteins, and neuropsychological tests. Besides, we performed different MANOVAs with further univariate analyses to differentiate groups. RESULTS: During follow-up, 8/30 aMCI-Aß + converted (26.6%) to AD dementia. There were no differences in multivariate analysis between groups in CSF biomarkers (p = 0.092) or at DMN functional connectivity (p = 0.814). aMCI-Aß + converters had smaller right HV than controls (p = 0.013), and greater right cingulum parahippocampal bundle radial diffusivity than controls (p < 0.001) and non-converters (p = 0.036). CONCLUSION: In this exploratory study, structural, but not functional, DMN connectivity alterations may differentiate aMCI-Aß + subjects who converted to AD dementia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer / Disfunción Cognitiva Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Neuroradiology Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer / Disfunción Cognitiva Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Neuroradiology Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania