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A systematic review and meta-analysis of the cyclic alternating pattern across the lifespan.
Migueis, D P; Lopes, M C; Ignacio, P S D; Thuler, L C S; Araujo-Melo, M H; Spruyt, K; Lacerda, G C B.
Afiliación
  • Migueis DP; PPGNEURO, Gaffree and Guinle University Hospital / Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil; Antonio Pedro University Hospital / Fluminense Federal University, Niterói, Brazil. Electronic address: debpetrungaro@gmail.com.
  • Lopes MC; Child and Adolescent Affective Disorder Program (PRATA), Department and Institute of Psychiatry at University of Sao Paulo Medical School, Sao Paulo, Brazil.
  • Ignacio PSD; PPGNEURO, Gaffree and Guinle University Hospital / Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Thuler LCS; National Cancer Institute, Rio de Janeiro, Brazil.
  • Araujo-Melo MH; PPGNEURO, Gaffree and Guinle University Hospital / Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Spruyt K; INSERM, Université de Paris, NeuroDiderot, France.
  • Lacerda GCB; PPGNEURO, Gaffree and Guinle University Hospital / Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil.
Sleep Med ; 85: 25-37, 2021 09.
Article en En | MEDLINE | ID: mdl-34271180
BACKGROUND: Cyclic alternating pattern (CAP) is the electroencephalogram (EEG) pattern described as a marker of sleep instability and assessed by NREM transient episodes in sleep EEG. It has been associated with brain maturation. The aim of this review was to evaluate the normative data of CAP parameters according to the aging process in healthy subjects through a systematic review and meta-analysis. METHODS: Two authors independently searched databases using PRISMA guidelines. Discrepancies were reconciled by a third reviewer. Subgroup analysis and tests for heterogeneity were conducted. RESULTS: Of 286 studies, 10 submitted a total of 168 healthy individuals to CAP analysis. Scoring of CAP can begin at 3 months of life, when K-complexes, delta bursts, or spindles can be recognized. Rate of CAP increased with age, mainly during the first 2 years of life, then decreased in adolescence, and increased in the elderly. The A1 CAP subtype and CAP rate were high in school-aged children during slow-wave sleep (SWS). A1 CAP subtypes were significantly more numerous in adolescents compared with other groups, while the elderly showed the highest amounts of A2 and A3 CAP subtypes. Our meta-analysis registered the lowest CAP rate in infants younger than 2 years old and the highest in the elderly. CONCLUSIONS: This review summarized the normative data of CAP in NREM sleep during the aging process. The CAP rate increased with age and sleep depth, especially during SWS. Parameters of CAP may reflect gender hormonal effects and neuroplasticity. More reports on CAP subtypes are needed for their reference values establishment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fases del Sueño / Longevidad Tipo de estudio: Systematic_reviews Límite: Adolescent / Aged / Child / Child, preschool / Humans / Infant Idioma: En Revista: Sleep Med Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fases del Sueño / Longevidad Tipo de estudio: Systematic_reviews Límite: Adolescent / Aged / Child / Child, preschool / Humans / Infant Idioma: En Revista: Sleep Med Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Países Bajos