The Prostacyclin Analogue, Treprostinil, Used in the Treatment of Pulmonary Arterial Hypertension, is a Potent Antagonist of TREK-1 and TREK-2 Potassium Channels.

Cunningham, Kevin P; Clapp, Lucie H; Mathie, Alistair; Veale, Emma L

Cunningham, Kevin P; Clapp, Lucie H; Mathie, Alistair; Veale, Emma L.

Afiliación

Cunningham KP; Medway School of Pharmacy, University of Kent and University of Greenwich, Chatham Maritime, United Kingdom.
Clapp LH; Wolfson Centre for Age-Related Diseases, King's College London, London, United Kingdom.
Mathie A; Institute of Cardiovascular Science, University College London, London, United Kingdom.
Veale EL; Medway School of Pharmacy, University of Kent and University of Greenwich, Chatham Maritime, United Kingdom.

Front Pharmacol ; 12: 705421, 2021.

Article en En | MEDLINE | ID: mdl-34267666

Palabras clave

BL-1249; K2P channels; TASK-1 channel; TREK-1 (tandem of pore domain in a weak inwardly rectifying K channel (Twik)-related K channels); TREK-2 channels; pulmonary arterial hypertension; treprostinil (PubChem CID: 6918140)

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Pharmacol Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Suiza

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