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Overexpression of helper T cell type 2-related molecules in the skin of patients with eosinophilic dermatosis of hematologic malignancy.
Maglie, Roberto; Ugolini, Filippo; De Logu, Francesco; Nassini, Romina; Simi, Sara; Nardiello, Pamela; Pasqualini, Elisa; Baroni, Gianna; Del Bianco, Elena; Massi, Daniela; Antiga, Emiliano.
Afiliación
  • Maglie R; Department of Health Sciences, Section of Dermatology, University of Florence, Florence, Italy. Electronic address: robertomaglie.med@libero.it.
  • Ugolini F; Department of Health Sciences, Section of Pathological Anatomy, University of Florence, Florence, Italy.
  • De Logu F; Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy.
  • Nassini R; Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy.
  • Simi S; Department of Health Sciences, Section of Pathological Anatomy, University of Florence, Florence, Italy.
  • Nardiello P; Department of Health Sciences, Section of Pathological Anatomy, University of Florence, Florence, Italy.
  • Pasqualini E; Department of Health Sciences, Section of Pathological Anatomy, University of Florence, Florence, Italy.
  • Baroni G; Department of Health Sciences, Section of Pathological Anatomy, University of Florence, Florence, Italy.
  • Del Bianco E; Department of Health Sciences, Section of Dermatology, University of Florence, Florence, Italy.
  • Massi D; Department of Health Sciences, Section of Pathological Anatomy, University of Florence, Florence, Italy.
  • Antiga E; Department of Health Sciences, Section of Dermatology, University of Florence, Florence, Italy.
J Am Acad Dermatol ; 87(4): 761-770, 2022 10.
Article en En | MEDLINE | ID: mdl-34265409
BACKGROUND: Eosinophilic dermatosis of hematologic malignancy (EDHM) is a rare dermatosis associated with blood tumors. OBJECTIVE: To characterize the expression of T-cell and B-cell markers and pruritogenic mediators in EDHM skin. METHODS: Immunohistochemical and immunofluorescence analysis were performed in 12 skin samples of EDHM, 11 samples of bullous pemphigoid (BP), and 5 samples from healthy controls (HC). Serum levels of interleukin (IL) 4 were analyzed in 11 patients with EDHM, 11 BP patients, and 5 HC by enzyme-linked immunosorbent assay. RESULTS: T-cell markers, including clusters of differentiation (CD) 3, CD4, CD8, and CD5 were significantly overexpressed in EDHM and BP skin compared to HC. A predominance of CD4+ over CD8+ cells and GATA3+ (helper T cell type 2 [Th2] marker) over T-bet+ (Th1 marker) cells were observed. FOXP3 expression was increased but the FOXP3/CD4 ratio was low. B-cell markers were under-represented, without significant differences between the 3 groups. IL-4 and IL-31 were significantly overexpressed in EDHM and BP compared to HC and colocalized with the Th2-associated marker GATA3. Eotaxin-1 was significantly overexpressed in EDHM compared to BP and HC. IL-4 serum concentration was significantly increased in EDHM and BP compared to HC. LIMITATIONS: Small sample size; retrospective design. CONCLUSIONS: Targeting Th2-related molecules, in particular IL-4, holds promise for EDHM management.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Penfigoide Ampolloso / Neoplasias Hematológicas Tipo de estudio: Observational_studies Límite: Humans Idioma: En Revista: J Am Acad Dermatol Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Penfigoide Ampolloso / Neoplasias Hematológicas Tipo de estudio: Observational_studies Límite: Humans Idioma: En Revista: J Am Acad Dermatol Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos