Your browser doesn't support javascript.
loading
Pathologic Complete Response Rates After Neoadjuvant Pertuzumab and Trastuzumab with Chemotherapy in Early Stage HER2-Positive Breast Cancer - Increasing Rates of Breast Conserving Surgery: A Real-World Experience.
Boér, Katalin; Kahán, Zsuzsanna; Landherr, László; Csoszi, Tibor; Máhr, Károly; Ruzsa, Ágnes; Horváth, Zsolt; Budai, Barna; Rubovszky, Gábor.
Afiliación
  • Boér K; Department of Medical Oncology, Szent Margit Hospital, Budapest, Hungary.
  • Kahán Z; Department of Oncotherapy, Faculty of Medicine, University of Szeged, Szeged, Hungary.
  • Landherr L; Department of Oncoradiology, Uzsoki Teaching Hospital, Budapest, Hungary.
  • Csoszi T; Department of Oncology, Jász-Nagykun-Szolnok Hetényi County Hospital, Szolnok, Hungary.
  • Máhr K; Department of Medical Oncology, Zala County Hospital, Zalaegerszeg, Hungary.
  • Ruzsa Á; Department of Oncology, Somogy County Kaposi Mór Hospital, Kaposvár, Hungary.
  • Horváth Z; Oncoradiological Center, Bács-Kiskun County Hospital, Kecskemét, Hungary.
  • Budai B; Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.
  • Rubovszky G; Department of Oncology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Pathol Oncol Res ; 27: 1609785, 2021.
Article en En | MEDLINE | ID: mdl-34257621
Purpose: The neoadjuvant use of pertuzumab and trastuzumab with chemotherapy improves the pathologic complete response (pCR) in early HER2+ breast cancer. The aim of this study was to determine the pCR rate obtained with dual HER2 blockade in routine clinical practice. The secondary and tertiary objective was to investigate the impact of neoadjuvant systemic therapy (NST) on performing breast-conserving surgery and survival data. Methods: This was a multicentre, retrospective, observational study in patients with stage II and III HER2+ early breast cancer who received pertuzumab and trastuzumab-based NST. Data were collected from patients' medical records. Results: Eighty-two patients were included in the study treated in 8 cancer centers in Hungary between March 2015 and January 2020. The study included women with a median age of 50.3 years. The majority of the patients (95%) received a sequence of anthracycline-based chemotherapy followed by docetaxel. pCR was achieved in 54% of the cases. As a result of NST a significant increase of conservative breast surgeries (33% vs. 3.6% planned, p = 0.0001) was observed. Ki67 expression and neutrophil-to-lymphocyte ratio (NLR) significantly predicted pCR. None of the variables were independent predictors of DFS. Conclusion: The pCR rate achieved in our study demonstrates the reproducibility of trial data in a real-world population. The rate of breast-conserving surgery was significantly increased.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Mastectomía Segmentaria / Protocolos de Quimioterapia Combinada Antineoplásica / Terapia Neoadyuvante Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Pathol Oncol Res Asunto de la revista: NEOPLASIAS / PATOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Mastectomía Segmentaria / Protocolos de Quimioterapia Combinada Antineoplásica / Terapia Neoadyuvante Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Pathol Oncol Res Asunto de la revista: NEOPLASIAS / PATOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Suiza