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Anaphylaxis to levetiracetam in an adolescent: a very rare occurence.
Kahraman, Seyma; Degermenci, Seyda; Oktay, Mehmet Ali; Menderes, Deniz; Güleryüz, Oksan Derinöz; Arhan, Ebru; Bakirtas, Arzu; Ertoy-Karagöl, Hacer Ilbilge.
Afiliación
  • Kahraman S; Department of Pediatrics, Gazi University Faculty of Medicine, Ankara, Turkey.
  • Degermenci S; Department of Pediatrics, Gazi University Faculty of Medicine, Ankara, Turkey.
  • Oktay MA; Department of Pediatrics, Gazi University Faculty of Medicine, Ankara, Turkey.
  • Menderes D; Divisions of Pediatric Neurology, Gazi University Faculty of Medicine, Ankara, Turkey.
  • Güleryüz OD; Divisions of Pediatric Emergency, Gazi University Faculty of Medicine, Ankara, Turkey.
  • Arhan E; Divisions of Pediatric Neurology, Gazi University Faculty of Medicine, Ankara, Turkey.
  • Bakirtas A; Divisions of Pediatric Allergy, Gazi University Faculty of Medicine, Ankara, Turkey.
  • Ertoy-Karagöl HI; Divisions of Pediatric Allergy, Gazi University Faculty of Medicine, Ankara, Turkey.
Turk J Pediatr ; 63(3): 506-509, 2021.
Article en En | MEDLINE | ID: mdl-34254497
BACKGROUND: Antiepileptic drugs (AEDs) are among the most common causes of severe delayed-type hypersensitivity reactions such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and Drug Reaction with Eosinophilia and Systemic Symptoms(DRESS) in children. These reactions are more commonly seen with aromatic AEDs such as phenytoin and carbamazepine than the non-aromatic or new generation AEDs. However immediate-type hypersensitivity reactions such as urticaria/angioedema, anaphylaxis are very rare with AEDs. CASE: Levetiracetam is an increasingly used new non-aromatic antiepileptic drug and reported to have a better safety profile in daily practice. We present the first adolescent case who developed an anaphylactic reaction with intravenous levetiracetam, not reported in this age group before in the literature. CONCLUSION: Hypersensitivity reactions in the form of anaphylaxis can be rarely observed with new generation AEDs. Therefore, when any antiepileptic drug is started on any patient, immediate type serious reactions such as anaphylaxis should be kept in mind, not only focusing on delayed reactions such as SJS, TEN,or DRESS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Stevens-Johnson / Anafilaxia Tipo de estudio: Diagnostic_studies Límite: Adolescent / Child / Humans Idioma: En Revista: Turk J Pediatr Año: 2021 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Turquía
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Stevens-Johnson / Anafilaxia Tipo de estudio: Diagnostic_studies Límite: Adolescent / Child / Humans Idioma: En Revista: Turk J Pediatr Año: 2021 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Turquía