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Effects of long-term norepinephrine treatment on normal immortalized ovarian and fallopian tube cells.
Dash, Sweta; Yoder, Sean; Mesa, Tania; Smith, Andrew; Cen, Ling; Eschrich, Steven; Armaiz-Pena, Guillermo N; Monteiro, Alvaro N A.
Afiliación
  • Dash S; Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Magnolia Drive, Tampa, FL, 1290233612, USA.
  • Yoder S; Cancer Biology Ph.D. Program, University of South Florida Tampa, Tampa, FL, 33612, USA.
  • Mesa T; Molecular Genomics Core Facility, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  • Smith A; Molecular Genomics Core Facility, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  • Cen L; Molecular Genomics Core Facility, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  • Eschrich S; Data Sharing Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  • Armaiz-Pena GN; Data Sharing Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  • Monteiro ANA; Department of Basic Sciences, Pharmacology Division, School of Medicine, Ponce Health Sciences University and Divisions of Cancer Biology and Women's Health, Ponce Research Institute, Ponce, PR, USA.
Sci Rep ; 11(1): 14334, 2021 07 12.
Article en En | MEDLINE | ID: mdl-34253763
Sustained adrenergic stimulation by norepinephrine (NE) contributes to ovarian carcinoma metastasis and impairment of chemotherapy response. Although the effect of sustained NE stimulation in cancer progression is well established, less is known about its role in cancer initiation. To determine the extent to which stress hormones influence ovarian cancer initiation, we conducted a long-term (> 3 months; > 40 population doublings) experiment in which normal immortalized fallopian tube secretory (iFTSEC283) and ovarian surface epithelial (iOSE11) cell lines and their isogenic pairs containing a p53 mutation (iFTSEC283p53R175H; iOSE11p53R175H), were continuously exposed to NE (100 nM, 1 µM, 10 µM). Fallopian tube cells displayed a p53-independent increase in proliferation and colony-forming ability in response to NE, while ovarian surface epithelial cells displayed a p53-independent decrease in both assays. Fallopian tube cells with mutant p53 showed a mild loss of chromosomes and TP53 status was also a defining factor in transcriptional response of fallopian tube cells to long-term NE treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Norepinefrina / Trompas Uterinas Límite: Female / Humans Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Norepinefrina / Trompas Uterinas Límite: Female / Humans Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido