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Age- and gender-related differences in brain tissue microstructure revealed by multi-component T2 relaxometry.
Canales-Rodríguez, Erick Jorge; Alonso-Lana, Silvia; Verdolini, Norma; Sarró, Salvador; Feria, Isabel; Montoro, Irene; Garcia-Ruiz, Beatriz; Jimenez, Esther; Varo, Cristina; Albacete, Auria; Argila-Plaza, Isabel; Lluch, Anna; Bonnin, C Mar; Vilella, Elisabet; Vieta, Eduard; Pomarol-Clotet, Edith; Salvador, Raymond.
Afiliación
  • Canales-Rodríguez EJ; FIDMAG Germanes Hospitalàries Research Foundation, Sant Boi de Llobregat, Barcelona, Spain; Mental Health Research Networking Center (CIBERSAM), Madrid, Spain; Signal Processing Laboratory (LTS5), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. Electronic address: erick.canal
  • Alonso-Lana S; FIDMAG Germanes Hospitalàries Research Foundation, Sant Boi de Llobregat, Barcelona, Spain; Mental Health Research Networking Center (CIBERSAM), Madrid, Spain; Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelo
  • Verdolini N; FIDMAG Germanes Hospitalàries Research Foundation, Sant Boi de Llobregat, Barcelona, Spain; Mental Health Research Networking Center (CIBERSAM), Madrid, Spain; Bipolar and Depressive Disorders Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, IDIBAPS, Barcelona, Spain.
  • Sarró S; FIDMAG Germanes Hospitalàries Research Foundation, Sant Boi de Llobregat, Barcelona, Spain; Mental Health Research Networking Center (CIBERSAM), Madrid, Spain.
  • Feria I; FIDMAG Germanes Hospitalàries Research Foundation, Sant Boi de Llobregat, Barcelona, Spain; Benito Menni CASM, Sant Boi de LLobregat, Barcelona, Spain.
  • Montoro I; Hospital Universitari Institut Pere Mata, Reus, Spain; Institut d'Investigació Sanitària Pere Virgili (IISPV)-CERCA, Reus, Spain; Universitat Rovira i Virgili (URV), Reus, Spain.
  • Garcia-Ruiz B; Hospital Universitari Institut Pere Mata, Reus, Spain; Institut d'Investigació Sanitària Pere Virgili (IISPV)-CERCA, Reus, Spain; Universitat Rovira i Virgili (URV), Reus, Spain.
  • Jimenez E; Mental Health Research Networking Center (CIBERSAM), Madrid, Spain; Bipolar and Depressive Disorders Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, IDIBAPS, Barcelona, Spain.
  • Varo C; Mental Health Research Networking Center (CIBERSAM), Madrid, Spain; Bipolar and Depressive Disorders Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, IDIBAPS, Barcelona, Spain.
  • Albacete A; FIDMAG Germanes Hospitalàries Research Foundation, Sant Boi de Llobregat, Barcelona, Spain; Mental Health Research Networking Center (CIBERSAM), Madrid, Spain.
  • Argila-Plaza I; FIDMAG Germanes Hospitalàries Research Foundation, Sant Boi de Llobregat, Barcelona, Spain.
  • Lluch A; Hospital Universitari Institut Pere Mata, Reus, Spain; Institut d'Investigació Sanitària Pere Virgili (IISPV)-CERCA, Reus, Spain.
  • Bonnin CM; Bipolar and Depressive Disorders Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, IDIBAPS, Barcelona, Spain.
  • Vilella E; Hospital Universitari Institut Pere Mata, Reus, Spain; Institut d'Investigació Sanitària Pere Virgili (IISPV)-CERCA, Reus, Spain; Universitat Rovira i Virgili (URV), Reus, Spain; Mental Health Research Networking Center (CIBERSAM), Madrid, Spain.
  • Vieta E; Mental Health Research Networking Center (CIBERSAM), Madrid, Spain; Bipolar and Depressive Disorders Unit, Hospital Clinic, Institute of Neurosciences, University of Barcelona, IDIBAPS, Barcelona, Spain.
  • Pomarol-Clotet E; FIDMAG Germanes Hospitalàries Research Foundation, Sant Boi de Llobregat, Barcelona, Spain; Mental Health Research Networking Center (CIBERSAM), Madrid, Spain.
  • Salvador R; FIDMAG Germanes Hospitalàries Research Foundation, Sant Boi de Llobregat, Barcelona, Spain; Mental Health Research Networking Center (CIBERSAM), Madrid, Spain.
Neurobiol Aging ; 106: 68-79, 2021 10.
Article en En | MEDLINE | ID: mdl-34252873
In spite of extensive work, inconsistent findings and lack of specificity in most neuroimaging techniques used to examine age- and gender-related patterns in brain tissue microstructure indicate the need for additional research. Here, we performed the largest Multi-component T2 relaxometry cross-sectional study to date in healthy adults (N = 145, 18-60 years). Five quantitative microstructure parameters derived from various segments of the estimated T2 spectra were evaluated, allowing a more specific interpretation of results in terms of tissue microstructure. We found similar age-related myelin water fraction (MWF) patterns in men and women but we also observed differential male related results including increased MWF content in a few white matter tracts, a faster decline with age of the intra- and extra-cellular water fraction and its T2 relaxation time (i.e. steeper age related negative slopes) and a faster increase in the free and quasi-free water fraction, spanning the whole grey matter. Such results point to a sexual dimorphism in brain tissue microstructure and suggest a lesser vulnerability to age-related changes in women.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Envejecimiento / Imagen por Resonancia Magnética / Caracteres Sexuales / Neuroimagen Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Male / Middle aged Idioma: En Revista: Neurobiol Aging Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Envejecimiento / Imagen por Resonancia Magnética / Caracteres Sexuales / Neuroimagen Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Male / Middle aged Idioma: En Revista: Neurobiol Aging Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos