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The relationship between job stress and job burnout moderated by BDNF rs6265 polymorphism.
Jia, Haiying; He, Mingwei; Zhang, Xiaoyue; Li, Yuling; He, Shu-Chang; Zhang, Xiang-Yang.
Afiliación
  • Jia H; Special Service Personnel Health Management Department, PLA Strategic Support Force Characteristic Medical Center, 9 Anxiang Beili, Chaoyang District, Beijing, 100101, China.
  • He M; Beijing Anzhen Hospital, Capital Medical University, 2 Anzhen Road, Chaoyang District, Beijing, 100029, China.
  • Zhang X; School of Psychological and Cognitive Sciences and Beijing Key Laboratory of Behavior and Mental Health, Peking University, 5 Yiheyuan Road, Haidian District, Beijing, 100871, China.
  • Li Y; School of Psychological and Cognitive Sciences and Beijing Key Laboratory of Behavior and Mental Health, Peking University, 5 Yiheyuan Road, Haidian District, Beijing, 100871, China.
  • He SC; School of Psychological and Cognitive Sciences and Beijing Key Laboratory of Behavior and Mental Health, Peking University, 5 Yiheyuan Road, Haidian District, Beijing, 100871, China. shuchangh@pku.edu.cn.
  • Zhang XY; Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing, 100101, China. zhangxy@psych.ac.cn.
Psychopharmacology (Berl) ; 238(10): 2963-2971, 2021 Oct.
Article en En | MEDLINE | ID: mdl-34245319
RATIONALE: Job stress can lead to job burnout, and BDNF polymorphism has been found to be involved in its psychopathological mechanism. Research needs a better understanding of the important role of gene × environment (i.e., BDNF polymorphism × job stress) interaction on job burnout. OBJECTIVE: This study aimed to explore how BDNF rs6265 polymorphism may moderate the relationship between job stress and job burnout. METHODS: Three hundred forty-one healthy participants (187 males and 154 females) from a Chinese university were included. The present study used a standardized questionnaire including demographic characteristics, job stress assessed by the House and Rizzo's Work Stress Scale, and job burnout assessed by the Maslach Burnout Inventory-General Survey. The BDNF rs6265 polymorphism was genotyped. RESULTS: Job stress showed a positive correlation with emotional exhaustion (p < 0.001), cynicism (p < 0.001), and reduced personal accomplishment (p < 0.01). The main effects of BDNF rs6265 polymorphism on emotional exhaustion and cynicism were significant [F(1,333) = 5.136, p = 0.024; F(1,333) = 4.175, p = 0.042, respectively]. The interaction between job stress and BDNF rs6265 on cynicism was significant (△ R2 = 0.013, p = 0.014) after controlling for age, sex, education, and position, indicating that individuals with BDNF rs6265 TT genotype showed higher level of cynicism when in high job stress. CONCLUSIONS: The results provided evidence for the association of BDNF gene rs6265 polymorphism, job stress, and their interaction with job burnout. Individuals with TT genotype in BDNF rs6265 might be susceptible to stressful situations, which would lead to cynicism.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Agotamiento Profesional / Factor Neurotrófico Derivado del Encéfalo / Estrés Laboral Límite: Female / Humans / Male Idioma: En Revista: Psychopharmacology (Berl) Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Agotamiento Profesional / Factor Neurotrófico Derivado del Encéfalo / Estrés Laboral Límite: Female / Humans / Male Idioma: En Revista: Psychopharmacology (Berl) Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania