A thrombin-PAR1/2 feedback loop amplifies thromboinflammatory endothelial responses to the viral RNA analogue poly(I:C).

Subramaniam, Saravanan; Ogoti, Yamini; Hernandez, Irene; Zogg, Mark; Botros, Fady; Burns, Robert; DeRousse, Jacob T; Dockendorff, Chris; Mackman, Nigel; Antoniak, Silvio; Fletcher, Craig; Weiler, Hartmut

Subramaniam, Saravanan; Ogoti, Yamini; Hernandez, Irene; Zogg, Mark; Botros, Fady; Burns, Robert; DeRousse, Jacob T; Dockendorff, Chris; Mackman, Nigel; Antoniak, Silvio; Fletcher, Craig; Weiler, Hartmut.

Afiliación

Subramaniam S; Blood Research Institute, Blood Center of Wisconsin, Versiti, Milwaukee, WI.
Ogoti Y; Blood Research Institute, Blood Center of Wisconsin, Versiti, Milwaukee, WI.
Hernandez I; Blood Research Institute, Blood Center of Wisconsin, Versiti, Milwaukee, WI.
Zogg M; Blood Research Institute, Blood Center of Wisconsin, Versiti, Milwaukee, WI.
Botros F; Blood Research Institute, Blood Center of Wisconsin, Versiti, Milwaukee, WI.
Burns R; Blood Research Institute, Blood Center of Wisconsin, Versiti, Milwaukee, WI.
DeRousse JT; Department of Chemistry, Marquette University, Milwaukee, WI.
Dockendorff C; Department of Chemistry, Marquette University, Milwaukee, WI.
Mackman N; Function Therapeutics LLC, Milwaukee, WI; and.
Antoniak S; Department of Medicine, Division of Hematology and Oncology, and.
Fletcher C; Department of Pathology and Laboratory Medicine, UNC Blood Research Center, University of North Carolina, Chapel Hill, NC.
Weiler H; Department of Pathology and Laboratory Medicine, UNC Blood Research Center, University of North Carolina, Chapel Hill, NC.

Blood Adv ; 5(13): 2760-2774, 2021 07 13.

Article en En | MEDLINE | ID: mdl-34242391

Asunto(s)

Receptor PAR-1; Trombina; Células Endoteliales; Retroalimentación; Humanos; ARN Viral

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombina / Receptor PAR-1 Límite: Humans Idioma: En Revista: Blood Adv Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos

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