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SARS-CoV-2 infection of the pancreas promotes thrombofibrosis and is associated with new-onset diabetes.
Qadir, Mirza Muhammad Fahd; Bhondeley, Manika; Beatty, Wandy; Gaupp, Dina D; Doyle-Meyers, Lara A; Fischer, Tracy; Bandyopadhyay, Ishitri; Blair, Robert V; Bohm, Rudolf; Rappaport, Jay; Lazartigues, Eric; Heide, Richard S Vander; Kolls, Jay K; Qin, Xuebin; Mauvais-Jarvis, Franck.
Afiliación
  • Qadir MMF; Section of Endocrinology and Metabolism, Deming Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA.
  • Bhondeley M; Southeast Louisiana Veterans Affairs Healthcare System, New Orleans, Louisiana, USA.
  • Beatty W; Tulane Center of Excellence in Sex-Based Biology and Medicine, New Orleans, Louisiana, USA.
  • Gaupp DD; Section of Endocrinology and Metabolism, Deming Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA.
  • Doyle-Meyers LA; Southeast Louisiana Veterans Affairs Healthcare System, New Orleans, Louisiana, USA.
  • Fischer T; Tulane Center of Excellence in Sex-Based Biology and Medicine, New Orleans, Louisiana, USA.
  • Bandyopadhyay I; Molecular Microbiology Imaging facility, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Blair RV; Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA.
  • Bohm R; Tulane National Primate Research Center, Covington, Louisiana, USA.
  • Rappaport J; Tulane National Primate Research Center, Covington, Louisiana, USA.
  • Lazartigues E; Section of Endocrinology and Metabolism, Deming Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA.
  • Heide RSV; Tulane National Primate Research Center, Covington, Louisiana, USA.
  • Kolls JK; Tulane National Primate Research Center, Covington, Louisiana, USA.
  • Qin X; Tulane National Primate Research Center, Covington, Louisiana, USA.
  • Mauvais-Jarvis F; Southeast Louisiana Veterans Affairs Healthcare System, New Orleans, Louisiana, USA.
JCI Insight ; 6(16)2021 08 23.
Article en En | MEDLINE | ID: mdl-34241597
Evidence suggests an association between severe acute respiratory syndrome-cornavirus-2 (SARS-CoV-2) infection and the occurrence of new-onset diabetes. We examined pancreatic expression of angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2), the cell entry factors for SARS-CoV-2, using publicly available single-cell RNA sequencing data sets, and pancreatic tissue from control male and female nonhuman primates (NHPs) and humans. We also examined SARS-CoV-2 immunolocalization in pancreatic cells of SARS-CoV-2-infected NHPs and patients who had died from coronavirus disease 2019 (COVID-19). We report expression of ACE2 in pancreatic islet, ductal, and endothelial cells in NHPs and humans. In pancreata from SARS-CoV-2-infected NHPs and COVID-19 patients, SARS-CoV-2 infected ductal, endothelial, and islet cells. These pancreata also exhibited generalized fibrosis associated with multiple vascular thrombi. Two out of 8 NHPs developed new-onset diabetes following SARS-CoV-2 infection. Two out of 5 COVID-19 patients exhibited new-onset diabetes at admission. These results suggest that SARS-CoV-2 infection of the pancreas may promote acute and especially chronic pancreatic dysfunction that could potentially lead to new-onset diabetes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Páncreas / Trombosis / Diabetes Mellitus / SARS-CoV-2 / COVID-19 Tipo de estudio: Risk_factors_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: JCI Insight Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Páncreas / Trombosis / Diabetes Mellitus / SARS-CoV-2 / COVID-19 Tipo de estudio: Risk_factors_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: JCI Insight Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos