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Pulmonary manifestations of IgG4­related disease in a South African patient.
Cilliers, J D; Eindhoven, S C; Louw, E; Koegelenberg, C F N; Irusen, E; Bruce-Brand, C; Allwood, B W.
Afiliación
  • Cilliers JD; Division of Pulmonology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa.
  • Eindhoven SC; Department of Respiratory Medicine, Franciscus Gasthuis and Vlietland, Rotterdam, The Netherlands.
  • Louw E; Division of Pulmonology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa.
  • Koegelenberg CFN; Division of Pulmonology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa.
  • Irusen E; Division of Pulmonology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa.
  • Bruce-Brand C; Division of Anatomical Pathology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  • Allwood BW; National Health Laboratory Service, Tygerberg Hospital, Cape Town, South Africa.
Afr J Thorac Crit Care Med ; 27(1)2021.
Article en En | MEDLINE | ID: mdl-34240046
Immunoglobin 4-related disease (IgG4-RD) is an auto-immune, multisystem inflammatory disorder characterised by storiform fibrosis, lymphoplasmacytic infiltration and obliterative phlebitis on histology. Its pathophysiology is not well understood, but is thought to occur due to complex interactions between T helper 2 cells, their cytokines, chemokines, and B lymphocytes that become dysregulated and produce dysfunctional immunoglobulins. Here, we present a case report of a 54-year-old man who was initially suspected of having lung cancer on imaging, but was ultimately diagnosed with IgG4-RD on histological analysis of a pneumonectomy specimen. Treatment with glucocorticoids can establish disease remission, with a small proportion of patients relapsing, if the diagnosis is made before significant fibrosis occurs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Afr J Thorac Crit Care Med Año: 2021 Tipo del documento: Article País de afiliación: Sudáfrica Pais de publicación: Sudáfrica
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Afr J Thorac Crit Care Med Año: 2021 Tipo del documento: Article País de afiliación: Sudáfrica Pais de publicación: Sudáfrica