Your browser doesn't support javascript.
loading
Association of single-nucleotide polymorphism on chromosome 9 and ischemic stroke in Heilongjiang province in China.
Jin, Ming; Zhang, Hao; Zhang, Qi; Li, Xueyan; Wu, Nan; Hu, Ying; Qiu, Changchun; Wang, Ningning; Zhang, Keyong.
Afiliación
  • Jin M; Institute of Polygenic Disease, Qiqihar Medical University Qiqihar, Heilongjiang, China.
  • Zhang H; Institute of Polygenic Disease, Qiqihar Medical University Qiqihar, Heilongjiang, China.
  • Zhang Q; Institute of Polygenic Disease, Qiqihar Medical University Qiqihar, Heilongjiang, China.
  • Li X; Institute of Polygenic Disease, Qiqihar Medical University Qiqihar, Heilongjiang, China.
  • Wu N; Institute of Polygenic Disease, Qiqihar Medical University Qiqihar, Heilongjiang, China.
  • Hu Y; Institute of Polygenic Disease, Qiqihar Medical University Qiqihar, Heilongjiang, China.
  • Qiu C; Institute of Polygenic Disease, Qiqihar Medical University Qiqihar, Heilongjiang, China.
  • Wang N; Department of Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences/Peking Union Medical College Beijing, China.
  • Zhang K; Institute of Polygenic Disease, Qiqihar Medical University Qiqihar, Heilongjiang, China.
Int J Clin Exp Pathol ; 14(6): 726-733, 2021.
Article en En | MEDLINE | ID: mdl-34239674
There is a significant correlation between ischemic stroke (IS) and chromosome 9. However, its status was uncertain in China's cold regions. 1920 IS patients, and 1920 healthy individuals were included in the study. Blood samples were collected. The association of SNPs with IS was evaluated by Sequenom, and logistic regression models adjusted for known risk factors of IS were constructed to assess the SNPs' associations in cases and controls. We found rs1333040 and rs2383207 were associated with IS, compared with primitive genotypes. The genotype CT of rs7027526 has a protective role during IS development, while the effect of the genotype TT is still not clear. These results changed after stratification by age and sex. In conclusion, rs1333040 and rs2383207 SNPs in CDKN2BAS are associated with ischemic stroke in the Chinese Han population. This study confirms the association between 9p21.3 and IS.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Int J Clin Exp Pathol Asunto de la revista: PATOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Int J Clin Exp Pathol Asunto de la revista: PATOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos