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Cell-penetrating, amphipathic cyclic peptoids as molecular transporters for cargo delivery.
Kim, Hyun-Soo; Lee, Yeongju; Shin, Min Hyeon; Lim, Hyun-Suk.
Afiliación
  • Kim HS; Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang 37673, South Korea. minh0812@postech.ac.kr hslim@postech.ac.kr.
  • Lee Y; Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang 37673, South Korea. minh0812@postech.ac.kr hslim@postech.ac.kr.
  • Shin MH; Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang 37673, South Korea. minh0812@postech.ac.kr hslim@postech.ac.kr.
  • Lim HS; Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang 37673, South Korea. minh0812@postech.ac.kr hslim@postech.ac.kr.
Chem Commun (Camb) ; 57(55): 6800-6803, 2021 Jul 08.
Article en En | MEDLINE | ID: mdl-34236370
Here we describe the design, synthesis, and biological evaluation of cell-penetrating, amphipathic cyclic peptoids as a novel class of molecular transporters. We demonstrated that macrocyclization, along with the introduction of hydrophobic residues, greatly enhanced cellular uptake of polyguanidine linear peptoids. The amphipathic cyclic peptoids showed an order of magnitude more efficient intracellular delivery ability, compared to a commonly used polyarginine cell-penetrating peptide, representing one of the best molecular transporters reported to date. Given the excellent cell-permeability, proteolytic stability, and ease of synthesis, the amphipathic cyclic peptoids would be broadly applicable to a wide range of clinical and biological applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Peptoides / Péptidos de Penetración Celular / Interacciones Hidrofóbicas e Hidrofílicas Límite: Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Peptoides / Péptidos de Penetración Celular / Interacciones Hidrofóbicas e Hidrofílicas Límite: Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido