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Early overnutrition in male mice negates metabolic benefits of a diet high in monounsaturated and omega-3 fats.
Glavas, Maria M; Hui, Queenie; Miao, Ian; Yang, Fan; Erener, Suheda; Prentice, Kacey J; Wheeler, Michael B; Kieffer, Timothy J.
Afiliación
  • Glavas MM; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Hui Q; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Miao I; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Yang F; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Erener S; Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Prentice KJ; Department of Physiology, University of Toronto, Toronto, Canada.
  • Wheeler MB; Department of Physiology, University of Toronto, Toronto, Canada.
  • Kieffer TJ; Department of Advanced Diagnostics, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Sci Rep ; 11(1): 14032, 2021 07 07.
Article en En | MEDLINE | ID: mdl-34234216
Overconsumption of saturated fats promotes obesity and type 2 diabetes. Excess weight gain in early life may be particularly detrimental by promoting earlier diabetes onset and potentially by adversely affecting normal development. In the present study we investigated the effects of dietary fat composition on early overnutrition-induced body weight and glucose regulation in Swiss Webster mice, which show susceptibility to high-fat diet-induced diabetes. We compared glucose homeostasis between a high-fat lard-based (HFL) diet, high in saturated fats, and a high-fat olive oil/fish oil-based (HFO) diet, high in monounsaturated and omega-3 fats. We hypothesized that the healthier fat profile of the latter diet would improve early overnutrition-induced glucose dysregulation. However, early overnutrition HFO pups gained more weight and adiposity and had higher diabetes incidence compared to HFL. In contrast, control pups had less weight gain, adiposity, and lower diabetes incidence. Plasma metabolomics revealed reductions in various phosphatidylcholine species in early overnutrition HFO mice as well as with diabetes. These findings suggest that early overnutrition may negate any beneficial effects of a high-fat diet that favours monounsaturated and omega-3 fats over saturated fats. Thus, quantity, quality, and timing of fat intake throughout life should be considered with respect to metabolic health outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Grasas Insaturadas en la Dieta / Ácidos Grasos Omega-3 / Hipernutrición / Metabolismo Energético / Dieta Alta en Grasa Límite: Animals Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Grasas Insaturadas en la Dieta / Ácidos Grasos Omega-3 / Hipernutrición / Metabolismo Energético / Dieta Alta en Grasa Límite: Animals Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido