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Potential Biomolecules Capable of Assessing Risk of Osteoporotic Fracture: A Scoping Review.
Liu, Jie Yu; Wang, Jia Xiang; Xu, Li; Deng, Fei Yan.
Afiliación
  • Liu JY; Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, Jiangsu, Suzhou 215123, China.
  • Wang JX; Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Jiangsu, Suzhou 215123, China.
  • Xu L; Department of Epidemiology and Biostatics, School of Public Health, Medical College of Soochow University, Jiangsu, Suzhou 215123, China.
  • Deng FY; Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, Jiangsu, Suzhou 215123, China.
Chin Med Sci J ; 36(2): 135-149, 2021 Jun 30.
Article en En | MEDLINE | ID: mdl-34231462
Osteoporosis as a systemic chronic skeletal disease is characterized by low bone mineral density and increased risk to osteoporotic fractures. Osteoporosis is prevalent in the middle-aged and elderly population, especially in the postmenopausal women. With population aging, osteoporosis has become a world-wide serious public health problem. Early recognition of the high-risk population followed by timely and efficient intervention and/or treatment is important for preventing osteoporotic fractures. In light of the high heritability and complex pathogenesis of osteoporosis, comprehensive consideration of vital biological/biochemical factors is necessary for accurate risk evaluation of fractures. For this purpose, we review recent research progress on molecules which can be applied to assess risk for osteoporotic fractures. Future integrative analyses and systematic evaluation of these molecules may facilitate developing novel methodologies and/or test strategies, i.e., biochips, for early recognition of osteoporosis, hence contributing to preventing osteoporotic fractures.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoporosis / Osteoporosis Posmenopáusica / Fracturas Osteoporóticas Tipo de estudio: Etiology_studies / Risk_factors_studies / Systematic_reviews Límite: Aged / Female / Humans / Middle aged Idioma: En Revista: Chin Med Sci J Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoporosis / Osteoporosis Posmenopáusica / Fracturas Osteoporóticas Tipo de estudio: Etiology_studies / Risk_factors_studies / Systematic_reviews Límite: Aged / Female / Humans / Middle aged Idioma: En Revista: Chin Med Sci J Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: China