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Prolonged SARS-CoV-2 RNA virus shedding and lymphopenia are hallmarks of COVID-19 in cancer patients with poor prognosis.
Goubet, Anne-Gaëlle; Dubuisson, Agathe; Geraud, Arthur; Danlos, François-Xavier; Terrisse, Safae; Silva, Carolina Alves Costa; Drubay, Damien; Touri, Lea; Picard, Marion; Mazzenga, Marine; Silvin, Aymeric; Dunsmore, Garett; Haddad, Yacine; Pizzato, Eugenie; Ly, Pierre; Flament, Caroline; Melenotte, Cléa; Solary, Eric; Fontenay, Michaela; Garcia, Gabriel; Balleyguier, Corinne; Lassau, Nathalie; Maeurer, Markus; Grajeda-Iglesias, Claudia; Nirmalathasan, Nitharsshini; Aprahamian, Fanny; Durand, Sylvère; Kepp, Oliver; Ferrere, Gladys; Thelemaque, Cassandra; Lahmar, Imran; Fahrner, Jean-Eudes; Meziani, Lydia; Ahmed-Belkacem, Abdelhakim; Saïdani, Nadia; La Scola, Bernard; Raoult, Didier; Gentile, Stéphanie; Cortaredona, Sébastien; Ippolito, Giuseppe; Lelouvier, Benjamin; Roulet, Alain; Andre, Fabrice; Barlesi, Fabrice; Soria, Jean-Charles; Pradon, Caroline; Gallois, Emmanuelle; Pommeret, Fanny; Colomba, Emeline; Ginhoux, Florent.
Afiliación
  • Goubet AG; Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre, France.
  • Dubuisson A; Gustave Roussy Cancer Campus, Villejuif, France.
  • Geraud A; Institut National de la Santé et de la Recherche Médicale, UMR1015, Gustave Roussy, Villejuif, France.
  • Danlos FX; Gustave Roussy Cancer Campus, Villejuif, France.
  • Terrisse S; Institut National de la Santé et de la Recherche Médicale, UMR1015, Gustave Roussy, Villejuif, France.
  • Silva CAC; Gustave Roussy Cancer Campus, Villejuif, France.
  • Drubay D; Département d'Oncologie Médicale, Gustave Roussy, Villejuif, France.
  • Touri L; Département d'Innovation Thérapeutique et d'Essais Précoces, Gustave Roussy, Villejuif, France.
  • Picard M; Gustave Roussy Cancer Campus, Villejuif, France.
  • Mazzenga M; Institut National de la Santé et de la Recherche Médicale, UMR1015, Gustave Roussy, Villejuif, France.
  • Silvin A; Gustave Roussy Cancer Campus, Villejuif, France.
  • Dunsmore G; Institut National de la Santé et de la Recherche Médicale, UMR1015, Gustave Roussy, Villejuif, France.
  • Haddad Y; Gustave Roussy Cancer Campus, Villejuif, France.
  • Pizzato E; Institut National de la Santé et de la Recherche Médicale, UMR1015, Gustave Roussy, Villejuif, France.
  • Ly P; Gustave Roussy Cancer Campus, Villejuif, France.
  • Flament C; Département de Biostatistique et d'Epidémiologie, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
  • Melenotte C; Institut National de la Santé et de la Recherche Médicale Oncostat, U1018, Equipe labellisée par la Ligue Contre le Cancer, Gustave Roussy, Villejuif, France.
  • Solary E; Gustave Roussy Cancer Campus, Villejuif, France.
  • Fontenay M; Médecine du travail, Gustave Roussy, Villejuif, France.
  • Garcia G; Gustave Roussy Cancer Campus, Villejuif, France.
  • Balleyguier C; Institut National de la Santé et de la Recherche Médicale, UMR1015, Gustave Roussy, Villejuif, France.
  • Lassau N; Institut Pasteur, Unit Biology and Genetics of the Bacterial Cell Wall, Paris, France.
  • Maeurer M; CNRS UMR2001, Paris, France.
  • Grajeda-Iglesias C; INSERM, Equipe Avenir, Paris, France.
  • Nirmalathasan N; Gustave Roussy Cancer Campus, Villejuif, France.
  • Aprahamian F; Institut National de la Santé et de la Recherche Médicale, UMR1015, Gustave Roussy, Villejuif, France.
  • Durand S; Gustave Roussy Cancer Campus, Villejuif, France.
  • Kepp O; Institut National de la Santé et de la Recherche Médicale, UMR1015, Gustave Roussy, Villejuif, France.
  • Ferrere G; Gustave Roussy Cancer Campus, Villejuif, France.
  • Thelemaque C; Institut National de la Santé et de la Recherche Médicale, UMR1015, Gustave Roussy, Villejuif, France.
  • Lahmar I; Gustave Roussy Cancer Campus, Villejuif, France.
  • Fahrner JE; Institut National de la Santé et de la Recherche Médicale, UMR1015, Gustave Roussy, Villejuif, France.
  • Meziani L; Gustave Roussy Cancer Campus, Villejuif, France.
  • Ahmed-Belkacem A; Institut National de la Santé et de la Recherche Médicale, UMR1015, Gustave Roussy, Villejuif, France.
  • Saïdani N; Gustave Roussy Cancer Campus, Villejuif, France.
  • La Scola B; Institut National de la Santé et de la Recherche Médicale, UMR1015, Gustave Roussy, Villejuif, France.
  • Raoult D; Gustave Roussy Cancer Campus, Villejuif, France.
  • Gentile S; Institut National de la Santé et de la Recherche Médicale, UMR1015, Gustave Roussy, Villejuif, France.
  • Cortaredona S; Gustave Roussy Cancer Campus, Villejuif, France.
  • Ippolito G; Institut National de la Santé et de la Recherche Médicale, UMR1015, Gustave Roussy, Villejuif, France.
  • Lelouvier B; Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre, France.
  • Roulet A; Gustave Roussy Cancer Campus, Villejuif, France.
  • Andre F; Institut National de la Santé et de la Recherche Médicale, U1287, Gustave Roussy, Villejuif, France.
  • Barlesi F; Département d'Hématologie, Gustave Roussy, Villejuif, France.
  • Soria JC; Université de Paris, Institut Cochin, Centre National de la Recherche Scientifique UMR8104, Institut National de la Santé et de la Recherche Médicale, Paris, France.
  • Pradon C; Service d'hématologie biologique, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris.Centre-Université de Paris, Paris, France.
  • Gallois E; Gustave Roussy Cancer Campus, Villejuif, France.
  • Pommeret F; Département d'Imagerie Médicale, Gustave Roussy, Villejuif, France.
  • Colomba E; Gustave Roussy Cancer Campus, Villejuif, France.
  • Ginhoux F; Département d'Imagerie Médicale, Gustave Roussy, Villejuif, France.
Cell Death Differ ; 28(12): 3297-3315, 2021 12.
Article en En | MEDLINE | ID: mdl-34230615
Patients with cancer are at higher risk of severe coronavirus infectious disease 2019 (COVID-19), but the mechanisms underlying virus-host interactions during cancer therapies remain elusive. When comparing nasopharyngeal swabs from cancer and noncancer patients for RT-qPCR cycle thresholds measuring acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in 1063 patients (58% with cancer), we found that malignant disease favors the magnitude and duration of viral RNA shedding concomitant with prolonged serum elevations of type 1 IFN that anticorrelated with anti-RBD IgG antibodies. Cancer patients with a prolonged SARS-CoV-2 RNA detection exhibited the typical immunopathology of severe COVID-19 at the early phase of infection including circulation of immature neutrophils, depletion of nonconventional monocytes, and a general lymphopenia that, however, was accompanied by a rise in plasmablasts, activated follicular T-helper cells, and non-naive Granzyme B+FasL+, EomeshighTCF-1high, PD-1+CD8+ Tc1 cells. Virus-induced lymphopenia worsened cancer-associated lymphocyte loss, and low lymphocyte counts correlated with chronic SARS-CoV-2 RNA shedding, COVID-19 severity, and a higher risk of cancer-related death in the first and second surge of the pandemic. Lymphocyte loss correlated with significant changes in metabolites from the polyamine and biliary salt pathways as well as increased blood DNA from Enterobacteriaceae and Micrococcaceae gut family members in long-term viral carriers. We surmise that cancer therapies may exacerbate the paradoxical association between lymphopenia and COVID-19-related immunopathology, and that the prevention of COVID-19-induced lymphocyte loss may reduce cancer-associated death.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Viral / Esparcimiento de Virus / SARS-CoV-2 / COVID-19 / Linfopenia / Neoplasias Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Death Differ Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Viral / Esparcimiento de Virus / SARS-CoV-2 / COVID-19 / Linfopenia / Neoplasias Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Death Differ Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido