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Sex-related differences in response to masseteric injections of glutamate and nerve growth factor in healthy human participants.
Alhilou, Abdelrahman M; Shimada, Akiko; Svensson, Camilla I; Svensson, Peter; Ernberg, Malin; Cairns, Brian E; Christidis, Nikolaos.
Afiliación
  • Alhilou AM; Department of Restorative Dentistry, College of Dentistry, Umm Al-Qura University, Makkah Al Mukarramah, Saudi Arabia. amhilou@uqu.edu.sa.
  • Shimada A; Division of Oral Diagnostics and Rehabilitation, Department of Dental Medicine, Karolinska Institutet, and Scandinavian Center for Orofacial Neurosciences (SCON), Box 4064, SE14104, Huddinge, Sweden. amhilou@uqu.edu.sa.
  • Svensson CI; Department of Geriatric Dentistry, Osaka Dental University, Osaka, 573-1144, Japan.
  • Svensson P; Department of Physiology and Pharmacology, Center for Molecular Medicine, Karolinska Institutet, 171 76, Stockholm, Sweden.
  • Ernberg M; Section of Orofacial Pain and Jaw Function, Department of Dentistry and Oral Health, Aarhus University, and Scandinavian Center for Orofacial Neurosciences (SCON), 5674+W3, Aarhus, Denmark.
  • Cairns BE; Division of Oral Diagnostics and Rehabilitation, Department of Dental Medicine, Karolinska Institutet, and Scandinavian Center for Orofacial Neurosciences (SCON), Box 4064, SE14104, Huddinge, Sweden.
  • Christidis N; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
Sci Rep ; 11(1): 13873, 2021 07 06.
Article en En | MEDLINE | ID: mdl-34230516
The neurophysiological mechanisms underlying NGF-induced masseter muscle sensitization and sex-related differences in its effect are not well understood in humans. Therefore, this longitudinal cohort study aimed to investigate the effect of NGF injection on the density and expression of substance P, NMDA-receptors and NGF by the nerve fibers in the human masseter muscle, to correlate expression with pain characteristics, and to determine any possible sex-related differences in these effects of NGF. The magnitude of NGF-induced mechanical sensitization and pain during oral function was significantly greater in women than in men (P < 0.050). Significant positive correlations were found between nerve fiber expression of NMDA-receptors and peak pain intensity (rs = 0.620, P = 0.048), and expression of NMDA-receptors by putative nociceptors and change in temporal summation pain after glutamate injection (rs = 0.561, P = 0.003). In women, there was a significant inverse relationship between the degree of NGF-induced mechanical sensitization and the change in nerve fiber expression of NMDA-receptors alone (rs = - 0.659, P = 0.013), and in combination with NGF (rs = - 0.764, P = 0.001). In conclusion, women displayed a greater magnitude of NGF-induced mechanical sensitization that also was associated with nerve fibers expression of NMDA-receptors, when compared to men. The present findings suggest that, in women, increased peripheral NMDA-receptor expression could be associated with masseter muscle pain sensitivity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caracteres Sexuales / Ácido Glutámico / Factor de Crecimiento Nervioso / Voluntarios Sanos / Inyecciones / Músculo Masetero Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caracteres Sexuales / Ácido Glutámico / Factor de Crecimiento Nervioso / Voluntarios Sanos / Inyecciones / Músculo Masetero Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Reino Unido