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Supplementation with Bifidobacterium breve BR03 and B632 strains improved insulin sensitivity in children and adolescents with obesity in a cross-over, randomized double-blind placebo-controlled trial.
Solito, Arianna; Bozzi Cionci, Nicole; Calgaro, Matteo; Caputo, Marina; Vannini, Lucia; Hasballa, Iderina; Archero, Francesca; Giglione, Enza; Ricotti, Roberta; Walker, Gillian Elisabeth; Petri, Antonella; Agosti, Emanuela; Bellomo, Giorgio; Aimaretti, Gianluca; Bona, Gianni; Bellone, Simonetta; Amoruso, Angela; Pane, Marco; Di Gioia, Diana; Vitulo, Nicola; Prodam, Flavia.
Afiliación
  • Solito A; Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Italy.
  • Bozzi Cionci N; Department of Agricultural and Food Sciences, University of Bologna, Italy.
  • Calgaro M; Department of Biotechnology, University of Verona, Italy.
  • Caputo M; Department of Health Sciences, University of Piemonte Orientale, Italy; SCDU Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Italy.
  • Vannini L; Department of Agricultural and Food Sciences, University of Bologna, Italy.
  • Hasballa I; SCDU Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Italy.
  • Archero F; Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Italy.
  • Giglione E; Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Italy.
  • Ricotti R; Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Italy.
  • Walker GE; Department of Health Sciences, University of Piemonte Orientale, Italy.
  • Petri A; Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Italy.
  • Agosti E; Department of Health Sciences, University of Piemonte Orientale, Italy.
  • Bellomo G; Clinical Biochemistry, Department of Health Sciences, University of Piemonte Orientale, Novara, Italy.
  • Aimaretti G; SCDU Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Italy.
  • Bona G; Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Italy.
  • Bellone S; Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Italy.
  • Amoruso A; Probiotical Research Srl, Novara, Italy.
  • Pane M; Probiotical Research Srl, Novara, Italy.
  • Di Gioia D; Department of Agricultural and Food Sciences, University of Bologna, Italy.
  • Vitulo N; Department of Biotechnology, University of Verona, Italy. Electronic address: nicola.vitulo@univr.it.
  • Prodam F; Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Italy; Department of Health Sciences, University of Piemonte Orientale, Italy; SCDU Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Italy. Electronic address: flavia.prodam
Clin Nutr ; 40(7): 4585-4594, 2021 07.
Article en En | MEDLINE | ID: mdl-34229263
BACKGROUND & AIMS: Variations in gut microbiota might impact metabolism leading to body weight excess. We assessed the impact of a probiotic supplementation in pediatric obesity on weight, metabolic alterations, selected gut microbial groups, and functionality. METHODS: Cross-over, double-blind, randomized control trial (BIFI-OBESE trial; NCT03261466). 101 youths (6-18 years, Tanner stage ≥2) with obesity and insulin-resistance on diet were randomized to 2 × 109 CFU/AFU/day of Bifidobacterium breve BR03 (DSM 16604) and B. breve B632 (DSM 24706) (51) or placebo (50) for 8 weeks with a 4-weeks wash-out period. RESULTS: All subjects (M/F 54/47) completed the first 8 weeks, and 82 (M/F 43/39) the last part without adverse events. Mixed-effects models revealed a carry-over effect on many variables in the entire study, narrowing the analysis to the first 8 weeks before the wash-out periods. All subjects improved metabolic parameters, and decreased weight and Escherichia coli counts. Probiotics improved insulin sensitivity at fasting (QUICKI, 0.013 CI95%0.0-0.03) and during OGTT (ISI, 0.654 CI95%-0.11-1.41). Cytokines, GLP1, and target microbial counts did not vary. Of 25 SCFAs, acetic acid and acetic acid pentyl-ester relative abundance remained stable in the probiotics, while increased in the placebo (p < 0.02). A signature of five butanoic esters identified three clusters, one of them had better glucose responses during probiotics. CONCLUSION: An 8 weeks treatment with B. breve BR03 and B632 had beneficial effects on insulin sensitivity in youths with obesity. Microbiota functionality could influence metabolic answers to probiotics. Long-term studies to confirm and enrich our findings are justified. Tailored probiotic treatments could be an additional strategy for obesity. TRIAL REGISTRATION: NCT03261466.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Probióticos / Obesidad Infantil / Microbioma Gastrointestinal / Bifidobacterium breve Tipo de estudio: Clinical_trials / Diagnostic_studies / Prognostic_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Clin Nutr Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Probióticos / Obesidad Infantil / Microbioma Gastrointestinal / Bifidobacterium breve Tipo de estudio: Clinical_trials / Diagnostic_studies / Prognostic_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Clin Nutr Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido