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The efficient synthesis and biological evaluation of justicidin B.
Kim, Taejung; Kim, Young-Joo; Jeong, Kyu-Hyuk; Park, Young-Tae; Kwon, Hyukjoon; Choi, Pilju; Ju, Ha-Neul; Yoon, Cheol Hee; Kim, Ji-Yool; Ham, Jungyeob.
Afiliación
  • Kim T; Korea Institute of Science and Technology (KIST), Natural Products Research Institute, Gangneung, Republic of Korea.
  • Kim YJ; Korea Institute of Science and Technology (KIST), Natural Products Research Institute, Gangneung, Republic of Korea.
  • Jeong KH; Korea Institute of Science and Technology (KIST), Natural Products Research Institute, Gangneung, Republic of Korea.
  • Park YT; Korea Institute of Science and Technology (KIST), Natural Products Research Institute, Gangneung, Republic of Korea.
  • Kwon H; Korea Institute of Science and Technology (KIST), Natural Products Research Institute, Gangneung, Republic of Korea.
  • Choi P; Korea Institute of Science and Technology (KIST), Natural Products Research Institute, Gangneung, Republic of Korea.
  • Ju HN; Korea Institute of Science and Technology (KIST), Natural Products Research Institute, Gangneung, Republic of Korea.
  • Yoon CH; Korea Institute of Science and Technology (KIST), Natural Products Research Institute, Gangneung, Republic of Korea.
  • Kim JY; Korea Institute of Science and Technology (KIST), Natural Products Research Institute, Gangneung, Republic of Korea.
  • Ham J; Division of Bio-Medical Science & Technology, University of Science and Technology (UST), Daejeon, Republic of Korea.
Nat Prod Res ; 37(1): 56-62, 2023 Jan.
Article en En | MEDLINE | ID: mdl-34227447
A facile new synthetic method for the preparation of a Type-A 1-arylnaphthalene lactone skeleton was developed and used to synthesise justicidin B and several derivatives. Key synthesis steps included Hauser-Kraus annulation of a phthalide intermediate and Suzuki-Miyaura cross coupling between a triflated naphthalene lactone intermediate and various potassium organotrifluoroborates. With two exceptions, the derivatives showed significant inhibitory effect on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse macrophages. Moreover, several compounds, including justicidin B, had marked cytotoxicity towards six human tumour cell lines.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lignanos / Dioxolanos Límite: Animals / Humans Idioma: En Revista: Nat Prod Res Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Imprimir
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lignanos / Dioxolanos Límite: Animals / Humans Idioma: En Revista: Nat Prod Res Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido