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Early initiation of hydroxyurea (hydroxycarbamide) using individualised, pharmacokinetics-guided dosing can produce sustained and nearly pancellular expression of fetal haemoglobin in children with sickle cell anaemia.
Quinn, Charles T; Niss, Omar; Dong, Min; Pfeiffer, Amanda; Korpik, Jennifer; Reynaud, Mary; Bonar, Holly; Kalfa, Theodosia A; Smart, Luke R; Malik, Punam; Ware, Russell E; Vinks, Alexander A; McGann, Patrick T.
Afiliación
  • Quinn CT; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
  • Niss O; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Dong M; Erythrocyte Diagnostic Laboratory, Cincinnati Children's Hospital, Cincinnati, OH, USA.
  • Pfeiffer A; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
  • Korpik J; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Reynaud M; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Bonar H; Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
  • Kalfa TA; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
  • Smart LR; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
  • Malik P; Erythrocyte Diagnostic Laboratory, Cincinnati Children's Hospital, Cincinnati, OH, USA.
  • Ware RE; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
  • Vinks AA; Erythrocyte Diagnostic Laboratory, Cincinnati Children's Hospital, Cincinnati, OH, USA.
  • McGann PT; Immunopathology Laboratory, Cincinnati Children's Hospital, Cincinnati, OH, USA.
Br J Haematol ; 194(3): 617-625, 2021 08.
Article en En | MEDLINE | ID: mdl-34227124
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemoglobina Fetal / Hidroxiurea / Anemia de Células Falciformes / Antidrepanocíticos Tipo de estudio: Prognostic_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Br J Haematol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemoglobina Fetal / Hidroxiurea / Anemia de Células Falciformes / Antidrepanocíticos Tipo de estudio: Prognostic_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Br J Haematol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido