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Dual anticancer and antibacterial activities of bismuth compounds based on asymmetric [NN'O] ligands.
Marzano, Ivana M; Tomco, Dajena; Staples, Richard J; Lizarazo-Jaimes, Edgar H; Gomes, Dawidson Assis; Bucciarelli-Rodriguez, Mônica; Guerra, Wendell; de Souza, Ívina P; Verani, Cláudio N; Pereira Maia, Elene C.
Afiliación
  • Marzano IM; Department of Chemistry, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte 31270-901, MG, Brazil.
  • Tomco D; Department of Chemistry, Wayne State University, 5101 Cass Ave., Detroit, MI 48202, USA.
  • Staples RJ; Department of Chemistry, Michigan State University, East Lansing, MI 48824, USA.
  • Lizarazo-Jaimes EH; Department of Chemistry, Universidade Federal de Viçosa, Rodovia MG-230, Km 7 - Zona Rural, Rio Paranaíba 38810-000, MG, Brazil.
  • Gomes DA; Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, 31270-901, MG, Brazil.
  • Bucciarelli-Rodriguez M; Departament of General Biology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, 31270-901, MG, Brazil.
  • Guerra W; Chemistry Institute, Universidade Federal de Uberlândia, Campus Santa Mônica, 38400-902 Uberlândia, MG, Brazil.
  • de Souza ÍP; Department of Chemistry, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte 31270-901, MG, Brazil; Department of Chemistry, Centro Federal de Educação Tecnológica de Minas Gerais, 30421-169 Belo Horizonte, MG, Brazil.
  • Verani CN; Department of Chemistry, Wayne State University, 5101 Cass Ave., Detroit, MI 48202, USA.
  • Pereira Maia EC; Department of Chemistry, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte 31270-901, MG, Brazil. Electronic address: elene@qui.ufmg.br.
J Inorg Biochem ; 222: 111522, 2021 09.
Article en En | MEDLINE | ID: mdl-34218087
Two new bismuth(III) complexes, [BiL1Cl2] (1) and [BiL2Cl2] (2), in which L1 is (2-hydroxy-4-6-di-tert-butylbenzyl-2-pyridylmethyl)amine and L2 is 2,4-diiodo-6-((pyridine-2-ylmethylamino)methyl)phenol, were synthesized and characterized by elemental and conductivity analyses, atomic absorption spectrometry, infrared and 1H NMR spectroscopies. The molecular structure of 1 reveals that the NN'O ligand forms a 1:1 complex with bismuth through coordination via the nitrogen of the aliphatic amine, the nitrogen of the pyridine ring and the oxygen of the phenolate. The coordination sphere is completed with two chloride anions in a distorted square pyramidal geometry. Bismuth exhibits the same coordination mode in compound 2. The cytotoxic activity of 1 and 2 was investigated in a chronic myelogenous leukemia cell line. The complexes are approximately three times more potent than the corresponding free ligands, with the IC50 values 0.30 and 0.38 µM for complex 1 and 2, respectively. To address the cellular mechanisms underlying cell demise, apoptosis was quantified by flow cytometry analysis. From 0.1 µM, both complexes induce apoptosis and there is a remarkable concentration-dependent increase in the population of cells in apoptosis. The complexes were also evaluated against Gram-positive and Gram-negative bacteria. Both inhibited the bacterial growth in a concentration-dependent way, with remarkable activity in some of the tested strains, for example, complex 2 was more active than its free ligand against all bacterial strains and approximately fourteen times more potent against S. dysenteriae and S. typhimurium.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complejos de Coordinación / Antibacterianos / Antineoplásicos Límite: Humans Idioma: En Revista: J Inorg Biochem Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complejos de Coordinación / Antibacterianos / Antineoplásicos Límite: Humans Idioma: En Revista: J Inorg Biochem Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos