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The Feasibility and Tolerability of Medium Chain Triglycerides in Women with a Catamenial Seizure Pattern on the Modified Atkins Diet.
Felton, Elizabeth A; Henry-Barron, Bobbie J; Jan, Amanda K; Shegelman, Abigail; Faltersack, Kelly; Vizthum, Diane; Cervenka, Mackenzie C.
Afiliación
  • Felton EA; Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
  • Henry-Barron BJ; Institute for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD 21202, USA.
  • Jan AK; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  • Shegelman A; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  • Faltersack K; Department of Clinical Nutrition Services, UW Health, Madison, WI 53792, USA.
  • Vizthum D; Institute for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD 21202, USA.
  • Cervenka MC; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Nutrients ; 13(7)2021 Jun 30.
Article en En | MEDLINE | ID: mdl-34208933
Ketogenic diet therapy (KDT), particularly modified Atkins diet (MAD), is increasingly recognized as a treatment for adults with epilepsy. Women with epilepsy (WWE) comprise 50% of people with epilepsy and approximately one in three have catamenial epilepsy. The purpose of this study was to determine whether adding a medium chain triglyceride emulsion to MAD to target catamenial seizures was feasible and well-tolerated. This was a prospective two-center study of pre-menopausal WWE with a catamenial seizure pattern on MAD. After a 1-month baseline interval with no changes in treatment, participants consumed betaquik® (Vitaflo International Ltd.) for 10 days each menstrual cycle starting 2 days prior to and encompassing the primary catamenial seizure pattern for five cycles. Participants recorded seizures, ketones, and menses, and completed surveys measuring tolerability. Sixteen women aged 20-50 years (mean 32) were enrolled and 13 (81.2%) completed the study. There was 100% adherence for consuming betaquik® in the women who completed the study and overall intervention adherence rate including the participants that dropped out was 81.2%. The most common side effects attributed to MAD alone prior to starting betaquik® were constipation and nausea, whereas abdominal pain, diarrhea, and nausea were reported after adding betaquik®. The high adherence rate and acceptable tolerability of betaquik® shows feasibility for future studies evaluating KDT-based treatments for catamenial seizures.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Convulsiones / Triglicéridos / Dieta Rica en Proteínas y Pobre en Hidratos de Carbono Límite: Adolescent / Adult / Humans / Middle aged Idioma: En Revista: Nutrients Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Convulsiones / Triglicéridos / Dieta Rica en Proteínas y Pobre en Hidratos de Carbono Límite: Adolescent / Adult / Humans / Middle aged Idioma: En Revista: Nutrients Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza