Your browser doesn't support javascript.
loading
Association of Matrix Metalloproteinases with Coronary Artery Calcification in Patients with CHD.
Polonskaya, Yana V; Kashtanova, Elena V; Murashov, Ivan S; Striukova, Evgenia V; Kurguzov, Alexey V; Stakhneva, Ekaterina M; Shramko, Viktoria S; Maslatsov, Nikolay A; Chernyavsky, Aleksandr M; Ragino, Yulia I.
Afiliación
  • Polonskaya YV; Research Institute of Internal and Preventive Medicine-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of IC&G SB RAS), 175/1 B. Bogatkova Str., 630089 Novosibirsk, Russia.
  • Kashtanova EV; Research Institute of Internal and Preventive Medicine-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of IC&G SB RAS), 175/1 B. Bogatkova Str., 630089 Novosibirsk, Russia.
  • Murashov IS; The Federal State Budgetary Institution "National Medical Research Center Named Academician E.N. Meshalkin" of the Ministry of Health of the Russian Federation, Rechkunovskaya Str., 15, 630055 Novosibirsk, Russia.
  • Striukova EV; Research Institute of Internal and Preventive Medicine-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of IC&G SB RAS), 175/1 B. Bogatkova Str., 630089 Novosibirsk, Russia.
  • Kurguzov AV; The Federal State Budgetary Institution "National Medical Research Center Named Academician E.N. Meshalkin" of the Ministry of Health of the Russian Federation, Rechkunovskaya Str., 15, 630055 Novosibirsk, Russia.
  • Stakhneva EM; Research Institute of Internal and Preventive Medicine-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of IC&G SB RAS), 175/1 B. Bogatkova Str., 630089 Novosibirsk, Russia.
  • Shramko VS; Research Institute of Internal and Preventive Medicine-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of IC&G SB RAS), 175/1 B. Bogatkova Str., 630089 Novosibirsk, Russia.
  • Maslatsov NA; Research Institute of Internal and Preventive Medicine-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of IC&G SB RAS), 175/1 B. Bogatkova Str., 630089 Novosibirsk, Russia.
  • Chernyavsky AM; The Federal State Budgetary Institution "National Medical Research Center Named Academician E.N. Meshalkin" of the Ministry of Health of the Russian Federation, Rechkunovskaya Str., 15, 630055 Novosibirsk, Russia.
  • Ragino YI; Research Institute of Internal and Preventive Medicine-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of IC&G SB RAS), 175/1 B. Bogatkova Str., 630089 Novosibirsk, Russia.
J Pers Med ; 11(6)2021 Jun 03.
Article en En | MEDLINE | ID: mdl-34205079
This work is aimed at studying the relationship of matrix metalloproteinases with calcification of the coronary arteries. The study included 78 people with coronary heart disease (CHD) and 36 without CHD. Blood and samples of coronary arteries obtained as a result of endarterectomy were examined. Serum levels of metalloproteinases (MMP) MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-10, MMP-12, and MMP-13 were determined by multiplex analysis. In blood vessel samples, MMP-1, MMP-3, MMP-7, and MMP-9 were determined by enzyme immunoassay; MMP-9 expression was evaluated by immunohistochemistry. Patients with CHD had higher serum levels of MMP-1, MMP-7, and MMP-12. Blood levels of MMP-1 and MMP-3 were associated with calcium levels, MMP-9 with osteoprotegerin and osteonectin, MMP-7 and MMP-10 with osteoprotegerin, MMP-12 with osteocalcin, and MMP-13 with osteopontin. Calcified plaques had higher levels of MMP-1 and MMP-9 compared to plaques without calcification. The relative risk of coronary arteries calcification was associated with MMP-9, which is confirmed by the results of immunohistochemistry. The results obtained indicate the participation of some MMPs, and especially MMP-9, in the calcification processes. The study can serve as a basis for the further study of the possibility of using MMP-1, MMP-7 and MMP-12 as potential biomarkers of CHD.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Risk_factors_studies Idioma: En Revista: J Pers Med Año: 2021 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Risk_factors_studies Idioma: En Revista: J Pers Med Año: 2021 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza