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Hyperactivated RAGE in Comorbidities as a Risk Factor for Severe COVID-19-The Role of RAGE-RAS Crosstalk.
Chiappalupi, Sara; Salvadori, Laura; Donato, Rosario; Riuzzi, Francesca; Sorci, Guglielmo.
Afiliación
  • Chiappalupi S; Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy.
  • Salvadori L; Interuniversity Institute of Myology (IIM), 06132 Perugia, Italy.
  • Donato R; Interuniversity Institute of Myology (IIM), 06132 Perugia, Italy.
  • Riuzzi F; Department of Translational Medicine, University of Piemonte Orientale, 28100 Novara, Italy.
  • Sorci G; Interuniversity Institute of Myology (IIM), 06132 Perugia, Italy.
Biomolecules ; 11(6)2021 06 12.
Article en En | MEDLINE | ID: mdl-34204735
The receptor for advanced glycation-end products (RAGE) is a multiligand receptor with a role in inflammatory and pulmonary pathologies. Hyperactivation of RAGE by its ligands has been reported to sustain inflammation and oxidative stress in common comorbidities of severe COVID-19. RAGE is essential to the deleterious effects of the renin-angiotensin system (RAS), which participates in infection and multiorgan injury in COVID-19 patients. Thus, RAGE might be a major player in severe COVID-19, and appears to be a useful therapeutic molecular target in infections by SARS-CoV-2. The role of RAGE gene polymorphisms in predisposing patients to severe COVID-19 is discussed. .
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Renina-Angiotensina / Estrés Oxidativo / Receptor para Productos Finales de Glicación Avanzada / COVID-19 / Inflamación Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Biomolecules Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Renina-Angiotensina / Estrés Oxidativo / Receptor para Productos Finales de Glicación Avanzada / COVID-19 / Inflamación Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Biomolecules Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza