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Is PTSD-Phenotype Associated with HPA-Axis Sensitivity?: The Endocannabinoid System in Modulating Stress Response in Rats.
Danan, Dor; Todder, Doron; Zohar, Joseph; Cohen, Hagit.
Afiliación
  • Danan D; Anxiety and Stress Research Unit, Beer-Sheva Mental Health Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Ministry of Health, Beer-Sheva 8461144, Israel.
  • Todder D; Anxiety and Stress Research Unit, Beer-Sheva Mental Health Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Ministry of Health, Beer-Sheva 8461144, Israel.
  • Zohar J; Post-Trauma Center, Sheba Medical Center, Tel Aviv 5262000, Israel.
  • Cohen H; Anxiety and Stress Research Unit, Beer-Sheva Mental Health Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Ministry of Health, Beer-Sheva 8461144, Israel.
Int J Mol Sci ; 22(12)2021 Jun 15.
Article en En | MEDLINE | ID: mdl-34203952
Endocannabinoids play a role in adaptation to stress and regulate the release of glucocorticoids in stressed and unstressed conditions. We recently found that basal corticosterone pulsatility may significantly impact the vulnerability for developing post-traumatic-stress-disorder (PTSD), suggesting that the endocannabinoid system may contribute to its development. To examine this, we exposed rats to predator scent stress (PSS). Behavioral reactions were recorded seven days post-PSS. Cerebrospinal fluid (CSF) was collected from anesthetized rats shortly after PSS exposure to determine the levels of 2-arachidonoyl glycerol (2-AG) and anandamide (AEA). To correlate between endocannabinoids and corticosterone levels, rats were placed in metabolic cages for urine collection. To assess the levels of endocannabinoids in specific brain regions, rats' brains were harvested one day after behavioral analysis for staining and fluorescence quantification. Moreover, 2-AG was elevated in the CSF of PTSD-phenotype rats as compared with other groups and was inversely correlated with corticosterone urinary secretion. Eight days post-PSS exposure, hippocampal and hypothalamic 2-AG levels and hippocampal AEA levels were significantly more reduced in the PTSD-phenotype group compared to other groups. We posit that maladaptation to stress, which is propagated by an abnormal activation of endocannabinoids, mediates the subsequent stress-induced behavioral disruption, which, later, reduces neuronal the expression of endocannabinoids, contributing to PTSD symptomology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Hipófiso-Suprarrenal / Trastornos por Estrés Postraumático / Estrés Psicológico / Endocannabinoides / Sistema Hipotálamo-Hipofisario Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Hipófiso-Suprarrenal / Trastornos por Estrés Postraumático / Estrés Psicológico / Endocannabinoides / Sistema Hipotálamo-Hipofisario Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Suiza