Synthesis of Novel Acyl Derivatives of 3-(4,5,6,7-Tetrabromo-1<i>H</i>-benzimidazol-1-yl)propan-1-ols-Intracellular TBBi-Based CK2 Inhibitors with Proapoptotic Properties.

Chojnacki, Konrad; Winska, Patrycja; Karatsai, Olena; Koronkiewicz, Miroslawa; Milner-Krawczyk, Malgorzata; Wielechowska, Monika; Redowicz, Maria Jolanta; Bretner, Maria; Borowiecki, Pawel

Synthesis of Novel Acyl Derivatives of 3-(4,5,6,7-Tetrabromo-1H-benzimidazol-1-yl)propan-1-ols-Intracellular TBBi-Based CK2 Inhibitors with Proapoptotic Properties.

Chojnacki, Konrad; Winska, Patrycja; Karatsai, Olena; Koronkiewicz, Miroslawa; Milner-Krawczyk, Malgorzata; Wielechowska, Monika; Redowicz, Maria Jolanta; Bretner, Maria; Borowiecki, Pawel.

Afiliación

Chojnacki K; Chair of Drug and Cosmetics Biotechnology, Faculty of Chemistry, Warsaw University of Technology, 00-664 Warsaw, Poland.
Winska P; Chair of Drug and Cosmetics Biotechnology, Faculty of Chemistry, Warsaw University of Technology, 00-664 Warsaw, Poland.
Karatsai O; Laboratory of Molecular Basis of Cell Motility, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland.
Koronkiewicz M; Department of Drug Biotechnology and Bioinformatics, National Medicines Institute, 00-725 Warsaw, Poland.
Milner-Krawczyk M; Chair of Drug and Cosmetics Biotechnology, Faculty of Chemistry, Warsaw University of Technology, 00-664 Warsaw, Poland.
Wielechowska M; Chair of Drug and Cosmetics Biotechnology, Faculty of Chemistry, Warsaw University of Technology, 00-664 Warsaw, Poland.
Redowicz MJ; Laboratory of Molecular Basis of Cell Motility, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland.
Bretner M; Chair of Drug and Cosmetics Biotechnology, Faculty of Chemistry, Warsaw University of Technology, 00-664 Warsaw, Poland.
Borowiecki P; Chair of Drug and Cosmetics Biotechnology, Faculty of Chemistry, Warsaw University of Technology, 00-664 Warsaw, Poland.

Int J Mol Sci ; 22(12)2021 Jun 10.

Article en En | MEDLINE | ID: mdl-34200807

Asunto(s)

Antineoplásicos/farmacología; Apoptosis; Bencimidazoles/química; Neoplasias de la Mama/tratamiento farmacológico; Quinasa de la Caseína II/antagonistas & inhibidores; Inhibidores de Proteínas Quinasas/síntesis química; Inhibidores de Proteínas Quinasas/farmacología; Antineoplásicos/síntesis química; Neoplasias de la Mama/enzimología; Neoplasias de la Mama/patología; Proliferación Celular; Femenino; Humanos; Células MCF-7; Relación Estructura-Actividad

Palabras clave

CK2 inhibitors; apoptosis; breast cancer; prodrug strategy; protein kinase CK2; tetrabromobenzimidazole

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bencimidazoles / Neoplasias de la Mama / Apoptosis / Quinasa de la Caseína II / Inhibidores de Proteínas Quinasas / Antineoplásicos Límite: Female / Humans Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza

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