Novel CDK9 inhibitor oroxylin A promotes wild-type P53 stability and prevents hepatocellular carcinoma progression by disrupting both MDM2 and SIRT1 signaling.

Yao, Jing-Yue; Xu, Shu; Sun, Yue-Ning; Xu, Ye; Guo, Qing-Long; Wei, Li-Bin

Yao, Jing-Yue; Xu, Shu; Sun, Yue-Ning; Xu, Ye; Guo, Qing-Long; Wei, Li-Bin.

Afiliación

Yao JY; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing, 210009, China.
Xu S; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing, 210009, China.
Sun YN; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing, 210009, China.
Xu Y; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing, 210009, China.
Guo QL; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing, 210009, China. anticancer_drug@163.com.
Wei LB; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing, 210009, China. wlbiws_1986@aliyun.com.

Acta Pharmacol Sin ; 43(4): 1033-1045, 2022 Apr.

Article en En | MEDLINE | ID: mdl-34188177

Asunto(s)

Carcinoma Hepatocelular; Neoplasias Hepáticas; Animales; Apoptosis; Carcinoma Hepatocelular/patología; Quinasa 9 Dependiente de la Ciclina/metabolismo; Flavonoides; Humanos; Neoplasias Hepáticas/patología; Ratones; Proteínas Proto-Oncogénicas c-mdm2/metabolismo; Sirtuina 1/metabolismo; Proteína p53 Supresora de Tumor/metabolismo

Palabras clave

Wt-p53 stabilization; hepatocellular carcinoma; inhibition of CDK9; oroxylin A

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Límite: Animals / Humans Idioma: En Revista: Acta Pharmacol Sin Asunto de la revista: FARMACOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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