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Malondialdehyde-Acetaldehyde Adduct Formation Decreases Immunoglobulin A Transport across Airway Epithelium in Smokers Who Abuse Alcohol.
Wyatt, Todd A; Warren, Kristi J; Wetzel, Tanner J; Suwondo, Troy; Rensch, Gage P; DeVasure, Jane M; Mosley, Deanna D; Kharbanda, Kusum K; Thiele, Geoffrey M; Burnham, Ellen L; Bailey, Kristina L; Yeligar, Samantha M.
Afiliación
  • Wyatt TA; Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, Nebraska; Department of Environmental, Agricultural and Occupational Health, University of Nebraska Medical Center, Omaha, Nebraska; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebr
  • Warren KJ; Department of Medicine-Pulmonary Division, University of Utah/VA Salt Lake Health Care System, Salt Lake City, Utah.
  • Wetzel TJ; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska.
  • Suwondo T; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska.
  • Rensch GP; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska.
  • DeVasure JM; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska.
  • Mosley DD; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska.
  • Kharbanda KK; Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, Nebraska; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska.
  • Thiele GM; Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, Nebraska; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska.
  • Burnham EL; Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Denver, Colorado.
  • Bailey KL; Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, Nebraska; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska.
  • Yeligar SM; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University, Atlanta, Georgia; Research Service, Atlanta VA Health Care System, Decatur, Georgia.
Am J Pathol ; 191(10): 1732-1742, 2021 10.
Article en En | MEDLINE | ID: mdl-34186073
Alcohol misuse and smoking are risk factors for pneumonia, yet the impact of combined cigarette smoke and alcohol on pneumonia remains understudied. Smokers who misuse alcohol form lung malondialdehyde-acetaldehyde (MAA) protein adducts and have decreased levels of anti-MAA secretory IgA (sIgA). Transforming growth factor-ß (TGF-ß) down-regulates polymeric Ig receptor (pIgR) on mucosal epithelium, resulting in decreased sIgA transcytosis to the mucosa. It is hypothesized that MAA-adducted lung protein increases TGF-ß, preventing expression of epithelial cell pIgR and decreasing sIgA. Cigarette smoke and alcohol co-exposure on sIgA and TGF-ß in human bronchoalveolar lavage fluid and in mice instilled with MAA-adducted surfactant protein D (SPD-MAA) were studied herein. Human bronchial epithelial cells (HBECs) and mouse tracheal epithelial cells were treated with SPD-MAA and sIgA and TGF-ß was measured. Decreased sIgA and increased TGF-ß were observed in bronchoalveolar lavage from combined alcohol and smoking groups in humans and mice. CD204 (MAA receptor) knockout mice showed no changes in sIgA. SPD-MAA decreased pIgR in HBECs. Conversely, SPD-MAA stimulated TGF-ß release in both HBECs and mouse tracheal epithelial cells, but not in CD204 knockout mice. SPD-MAA stimulated TGF-ß in alveolar macrophage cells. These data show that MAA-adducted surfactant protein stimulates lung epithelial cell TGF-ß, down-regulates pIgR, and decreases sIgA transcytosis. These data provide a mechanism for the decreased levels of sIgA observed in smokers who misuse alcohol.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoglobulina A / Alcoholismo / Epitelio / Fumadores / Acetaldehído / Pulmón / Malondialdehído Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Am J Pathol Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoglobulina A / Alcoholismo / Epitelio / Fumadores / Acetaldehído / Pulmón / Malondialdehído Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Am J Pathol Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos