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MiR-32-3p Regulates Myocardial Injury Induced by Microembolism and Microvascular Obstruction by Targeting RNF13 to Regulate the Stability of Atherosclerotic Plaques.
Huang, Dajun; Liu, Yang; Gao, Le; Wei, Xiaomin; Xu, Yuli; Cai, Ruping; Su, Qiang.
Afiliación
  • Huang D; Department of Cardiology, Wuzhou Gongren Hospital, No.1, Nansan Lane, Goadi Road, Wuzhou, 543001, Guangxi, China.
  • Liu Y; Department of Cardiology, The Second Nanning People's Hospital, The Third Affiliated Hospital of Guangxi Medical University, No.13, Dancun Road, Nanning, 530031, Guangxi, China.
  • Gao L; Department of Cardiology, Wuzhou Gongren Hospital, No.1, Nansan Lane, Goadi Road, Wuzhou, 543001, Guangxi, China.
  • Wei X; Department of Cardiology, Wuzhou Gongren Hospital, No.1, Nansan Lane, Goadi Road, Wuzhou, 543001, Guangxi, China.
  • Xu Y; Department of Cardiology, The Affiliated Hospital of Guilin Medical University, No.15, Lequn Road, Guilin, 541001, Guangxi, China.
  • Cai R; Department of Cardiology, The Affiliated Hospital of Guilin Medical University, No.15, Lequn Road, Guilin, 541001, Guangxi, China.
  • Su Q; Department of Cardiology, The Affiliated Hospital of Guilin Medical University, No.15, Lequn Road, Guilin, 541001, Guangxi, China. drsuqiang@163.com.
J Cardiovasc Transl Res ; 15(1): 143-166, 2022 02.
Article en En | MEDLINE | ID: mdl-34185281
This study aimed to explore the molecular mechanism of myocardial protection. The effects of miR-32-3p and ring finger protein 13 (RNF13) on endoplasmic reticulum (ER) stress-induced apoptosis of A-10 cells and human umbilical vein endothelial cells (HUVEC) were detected using flow cytometry. The effects of miR-32-3p and phenylbutyric acid (PBA) on plaque instability and myocardial tissue injury in rats were investigated after establishment of arterial plaque model and embolization model and treatment with miR-32-3p-antagomir and PBA. RNF13, which was differentially expressed in myocardial infarction, was the direct target gene of miR-32-3p. MiR-32-3p inhibited RNF13 expression and targeted RNF13 to inhibit ER stress-induced cell apoptosis. Furthermore, inhibiting miR-32-3p expression induced arterial plaque instability by reducing survival, increasing pathological lesions in arterial tissue, up-regulating ER stress-related proteins, and regulating the expressions of apoptosis-related proteins in the model rats. However, PBA reversed the effects of miR-32-3p-antagomir on the model rats. MiR-32-3p regulates myocardial injury induced by micro-embolism and micro-vascular obstruction by targeting RNF13 to regulate the stability of atherosclerotic plaques.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: MicroARNs / Ubiquitina-Proteína Ligasas / Placa Aterosclerótica / Estrés del Retículo Endoplásmico / Infarto del Miocardio Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Cardiovasc Transl Res Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: MicroARNs / Ubiquitina-Proteína Ligasas / Placa Aterosclerótica / Estrés del Retículo Endoplásmico / Infarto del Miocardio Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Cardiovasc Transl Res Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos